Sheehan's syndrome

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Related to Sheehan's syndrome: Asherman's syndrome


 [nĕ-kro´sis, ne-kro´sis] (Gr.)
the morphological changes indicative of cell death caused by enzymatic degradation.
aseptic necrosis necrosis without infection or inflammation.
acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. See also lower nephron nephrosis.
Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.
bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.
caseous necrosis caseation (def. 2).
central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.
cheesy necrosis caseation (def. 2).
coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.
colliquative necrosis liquefactive necrosis.
fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.
liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.
massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.
moist necrosis necrosis in which the dead tissue is wet and soft.
postpartum pituitary necrosis see postpartum pituitary necrosis.
selective myocardial cell necrosis myofibrillar degeneration.
subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.
Zenker's necrosis hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.


occurring after childbirth, with reference to the mother.
postpartum pituitary necrosis necrosis of the pituitary during the postpartum period, resulting from an infarct; it is often associated with shock and excessive uterine bleeding during delivery, and leads to variable patterns of hypopituitarism. Called also Sheehan's syndrome.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Sheehan syndrome

A condition that follows postpartum uterine haemorrhage severe enough to cause circulatory collapse, resulting in pituitary necrosis and hypopituitarism, especially if disseminated intravascular coagulation (DIC) was also present.

Clinical findings
Galactorrhoea, amenorrhoea or oligomenorrhoea, secondary hypothyroidism, cold intolerance, hypotension, bradycardia, weight gain, hair loss, adrenal insufficiency, fatigue, loss of libido, hypoglycaemia, hyponatraemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Sheehan's syndrome

The effects of destruction of the front part of the PITUITARY GLAND by loss of its blood supply (infarction) following severe bleeding from the womb after delivery of a baby (postpartum haemorrhage). There is failure of milk production, loss of body hair, absence of menstruation, lethargy and other effects of underaction of the endocrine glands. (Professor Harold Leeming Sheehan, 1900–86, English physician).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
An interesting finding of increased hypoglycemia in Sheehan's syndrome compared to other causes is speculative, but not significant (p=0.08) in our study.
Our patients with Sheehan's syndrome also had significantly higher heart rate compared to other causes of hypopituitarism (p=0.04), reflecting the hemodynamic changes associated with the chronic adaptation of cardiovascular system associated with adrenal insufficiency well reported in acute as well as chronic cases.
Finally, while it is plausible that other antibodies not measured in our study may play a role in the genesis of Sheehan's syndrome, to our knowledge, for the first time in a prospective study, we assessed the most common anti-pituitary antibodies described in the body of evidence.
Peaceman, "The incidence of Sheehan's syndrome after obstetric hemorrhage," Fertility and Sterility, vol.
As the clinical features of Sheehan's syndrome are often subtle, years may pass before a definitive diagnosis is made.
In conclusion, apart from the already-known associations of Sheehan's syndrome, clinicians must always keep in mind that a combination of Sheehan's syndrome with major depressive disorder could exist.
Clinical report of 28 patients of Sheehan's syndrome. Endocrine Journal.
Epidemiological aspects of postpartum pituitary hypofunction (Sheehan's syndrome).
The idea of reporting this case is not just rarity of this case but to give a message that Good antenatal and delivery care is a must to be able to prevent Sheehan's syndrome.
A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia.
In diagnosed case of Sheehan's syndrome, if a finding of pancytopenia appears and workup for haematological disorders proves uncontributory, it can be safely ascribed to the Sheehan's syndrome itself.
Sheehan's syndrome as a rare cause of anemia secondary to hypopituitarism.