Shadow Plaque

A typical finding in the CNS of multiple sclerosis, which corresponds to an area of demyelination, often seen by gross examination
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14,21) In the majority of these (Pattern 2) cases, active lesions were typically perivenous in location, characterized by the precipitation of activated complement and IgG on degenerating myelin sheaths and associated with the presence of remyelinating shadow plaques elsewhere in the CNS.
Such pre-phagocytic lesions, and nearby active lesions derived from the same patients, also exhibit a spectrum of pathological changes, including complement deposition on lesional myelin, in individual cases; and remyelinating shadow plaques, which were notably absent in the Pattern 3 cases described by Lucchinetti et al.
Those shadow plaques suggest MS "is not a totally irreversible problem," says Dale E.