Diagnostic Criteria for Sezary Syndrome Significant erythroderma Demonstrating a clonal T-cell population in blood; T-cell gene rearrangement studies by PCR Absolute peripheral blood Sezary cell
count: > 1000 Sezary cells
/[micro]L Alternatively, an increased CD4/CD8 ratio of more than 10 (or) increased CD4 count with an abnormal phenotype ([CD4.
Peripheral Sezary cell
counts were documented on a 10-point scale; improvement of redness, itching and scale was noted during a 16-week trial period.
One patient with Sezary syndrome (an advanced hematological expression of CTCL) had a rapid and dramatic fall in blood Sezary cell
(SC) count with apoptotic SCs visible following treatment with Targretin capsules.
Mild nuclear-contour irregularities may occur, but the classic cerebriform nuclei of Sezary cells
are not present.
6,7 The association of PEO with malignancy and laboratory features like circulating Sezary cells
, hypereosinophilia and raised IgE levels point towards the heterogenous nature of this entity.
Bone marrow aspirate showed 10% lymphocyte, 5% plasmo-cytes without Sezary cells
One reason for which ECP may be ineffective in patients with patch stage MF is the fact that the majority of patients treated had low levels of circulating Sezary cells
in the peripheral blood (26).
Other important laboratory studies include complete blood count--with differential--as well as peripheral smear looking for Sezary cells
, lactic dehydrogenase (LDH), liver function tests, and uric acid.
Here she was responsible for QC/QA and staff training as well as performing bone marrow diffs, smears, and initial reading for Sezary cells
and diagnostic differentials on the full spectrum of leukemia through to hemoglobinopathies.
Immunophenotypic identification of Sezary cells
in peripheral blood.
Identifying Sezary cells
in the peripheral blood remains a dilemma for many clinicians.
Rexinoids Modulate Immune Response in CLL and Sezary Cells