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Diagnostic Criteria for Sezary Syndrome Significant erythroderma Demonstrating a clonal T-cell population in blood; T-cell gene rearrangement studies by PCR Absolute peripheral blood Sezary cell count: > 1000 Sezary cells/[micro]L Alternatively, an increased CD4/CD8 ratio of more than 10 (or) increased CD4 count with an abnormal phenotype ([CD4.
Mild nuclear-contour irregularities may occur, but the classic cerebriform nuclei of Sezary cells are not present.
6,7 The association of PEO with malignancy and laboratory features like circulating Sezary cells, hypereosinophilia and raised IgE levels point towards the heterogenous nature of this entity.
Bone marrow aspirate showed 10% lymphocyte, 5% plasmo-cytes without Sezary cells.
One reason for which ECP may be ineffective in patients with patch stage MF is the fact that the majority of patients treated had low levels of circulating Sezary cells in the peripheral blood (26).
Other important laboratory studies include complete blood count--with differential--as well as peripheral smear looking for Sezary cells, lactic dehydrogenase (LDH), liver function tests, and uric acid.
Here she was responsible for QC/QA and staff training as well as performing bone marrow diffs, smears, and initial reading for Sezary cells and diagnostic differentials on the full spectrum of leukemia through to hemoglobinopathies.
Identifying Sezary cells in the peripheral blood remains a dilemma for many clinicians.