Albert, French dermatologist, 1880-1956. See: Sézary cell, Sézary erythroderma, Sézary syndrome.
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Gloucester Pharmaceuticals announced today that ISTODAX([R]) (romidepsin) has been included in the updated National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology[TM] as a suggested systemic treatment option for patients with mycosis fungoides and Sezary syndrome--two of the most common types of cutaneous T-cell lymphoma (CTCL).
Responses were observed at all stages of disease, including an overall response rate of 42% in evaluable patients with Stage IIB or greater disease, including patients with Sezary syndrome.
Romidepsin also demonstrated high response rates in patients with Stage IIB or greater disease, including patients with Sezary syndrome.
Cutaneous T-cells lymphomas, or CTCLs, are comprised of a number of non-Hodgkin's T-cell lymphomas, including mycosis fungoides and Sezary syndrome, which have their primary manifestations in the skin.
CTCL is a group of diseases, including mycosis fungoides and Sezary syndrome, which constitute types of non-Hodgkin's lymphoma in which certain cells of the lymph system (T cells) become cancerous and affect the skin and can affect other organs.
For the phase 3 study (MAVORIC), 372 patients with previously treated stage IB to stage IVB CTCL (mycosis fungoides or Sezary syndrome) without large-cell transformation received mogamulizumab (1.
Mogamulizumab is currently being developed for the treatment of Mycosis Fungoides (MF) and Sezary Syndrome (SS), for use in adult patients who have received at least one prior systemic therapy.
Mild nuclear-contour irregularities may occur, but the classic cerebriform nuclei of Sezary cells are not present.
Cutaneous mastocytosis was reported in 1936 for the firts time by Sezary and Chauvillon (17).
While our criteria are helpful for the diagnosis of adult/adolescent AD, it is necessary to differentiate some diseases that might satisfy this set of criteria such as hyper-eosinophilic syndrome, Wiscott–Aldrich syndrome, Netherton syndrome, hyper-IgE syndrome, Sezary disease and other diseases.
Guidelines for phototherapy of mycosis fungoides and Sezary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium.