sex hormone-binding globulin


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sex hor·mone-bind·ing glob·u·lin (SHBG),

a plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

sex hor·mone-bind·ing glob·u·lin

(SHBG) (seks hōrmōn-bīnding globyū-lin)
Plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men.
Synonym(s): testosterone-estrogen-binding globulin.

sex hormone-binding globulin

A plasma glycoprotein that binds androgens or estrogens, leaving small concentrations of free hormones to circulate in the blood.
See also: globulin
References in periodicals archive ?
Yeap et al., "Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies," PLoS One, vol.
Al-Busaidi et al., "Common variants in the sex hormone-binding globulin (SHBG) gene influence SHBG levels in women with polycystic ovary syndrome," Annals of Nutrition and Metabolism, vol.
Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men.
Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site.
Clinical Disorders Affecting Sex Hormone-Binding Globulin
Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia.
A complete evaluation of andropause should include total serum testosterone, serum protein-bound testosterone, serum free-free fraction testosterone, serum sex hormone-binding globulin, serum LH, and serum estradiol.
However, measurements of total T or total E levels do not accurately reflect the actual levels of these steroids available to tissues because the fraction bound to sex hormone-binding globulin (SHBG) does not freely pass to target tissues.
On the other hand, fasting insulin concentrations were significantly increased, and sex hormone-binding globulin levels were significantly decreased, compared with controls only, in the PP subgroup.
Sex hormone-binding globulin and glucose tolerance in postmenopausal women.