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Among many people living near the Seveso accident, blood concentrations spiked to between 10s and 1,000s of parts per trillion.
Report of the Parliamentary Commission of Inquiry on the Seveso accident, deposited on 28 July 1978.
The results of this study clearly indicate that continuous exposure of males starting from low concentrations of dioxin before and after birth due to the mother being exposed during the Seveso accident, and then due to breast-feeding during "neonatal minipuberty," results in a permanent impairment of the reproductive system {reduction of about 50% of sperm concentration and total sperm count and about 20% of sperm progressive motility, and increase of FSH with decrease of inhibin B) in young adulthood.
background totals of dioxins have dropped since 1976, she says, they were "probably in the neighborhood of 40 to 60 [ppt in body fat]" at the time of the Seveso accident.
New epidemiologic evidence consists primarily of positive exposure-response analyses in several of the industrial cohorts, as well as evidence of excesses of several specific cancers in the Seveso accident cohort.
In 1997, the epidemiologic evidence consisted of studies of a) several industrial cohorts of chemical workers producing chlorophenol and phenoxy herbicides; b) cohorts of civilian or military pesticide applicators; c) the Seveso accident cohort; and d) numerous community-based studies.
Nearly 20 years after the Seveso accident, the levels of AhR transcripts (measured in uncultured peripheral blood lymphocytes) were decreased in the exposed subjects and negatively correlated with current plasma TCDD levels (Landi et al.
Because of all these facts, 25 years after the Seveso accident we invited subjects exposed to TCDD in 1976 in their childhood to receive a dental examination.
Twenty-five years after the Seveso accident we found that serum TCDD levels in childhood were associated with the presence of developmental enamel defects in the permanent dentition.
Increased total hemolytic complement activity (CH50) was described in children examined immediately after the Seveso accident (Pocchiari et al.
Nearly 20 years after the Seveso accident, we found a suppression of IgG plasma levels in subjects exposed to TCDD.
In: Chemistry, Man, and Environment: The Seveso Accident 20 Years On: Monitoring, Epidemiology, and Remediation (Ballarin-Denti A, Bertazzi PA, Facchetti S, Mocarelli P, eds).