Sertoli cells


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Related to Sertoli cells: Leydig cells, Leydig

Ser·to·li cells

(sĕr-tō'lē),
elongated cells in the seminiferous tubules that ensheathe spermatogenic cells, providing a microenvironment that supports spermiogenesis and spermatocytogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli cells.
Synonym(s): nurse cells

Ser·to·li cells

(ser-tō'lē selz)
Elongated cells in the seminiferous tubules that ensheathe spermatids, providing a microenvironment that supports spermiogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli cells.

Sertoli cells

Elongated cells in the walls of the seminiferous tubules that closely surround (‘nurse’) the spermatids, encouraging spermatogenesis. Together, they provide a blood-testis barrier and secrete an androgen-binding protein. (Enrico Sertoli, Italian histologist, 1842–1910).

Sertoli cells

or

nurse cells

large nutritive cells occurring in the wall of SEMINIFEROUS TUBULES that serve to nourish the developing sperm. They are named after the Italian histologist, E. Sertoli.

Sertoli,

Enrico, Italian histologist, 1842-1910.
Sertoli cell tumor - a testicular tumor. Synonym(s): androblastoma
Sertoli cells - elongated cells in the seminiferous tubules to which spermatids are attached during spermiogenesis. Synonym(s): nurse cells
Sertoli columns
Sertoli-cell-only syndrome - the absence from the seminiferous tubules of the testes of germinal epithelium, Sertoli cells alone being present. Synonym(s): Del Castillo syndrome
References in periodicals archive ?
Testicular cells were isolated from testis samples of two months old lambs and co- cultured with Sertoli cells. The Sertoli cells which proliferated and created a monolayer of feeder cells and spermatogonia cells were colonized.
Round spermatids, spermatocytes in preleptotene and pachytene stages, nuclei of Sertoli cells, and type A and type B spermatogonia were also observed in this stage.
Ishikawa reported that in humans, the leptin receptor is present in testicular tissue and confined only to Leydig cells and is not expressed by Sertoli cells, germ cells, or spermatozoa [28].
Under observation with highest magnification (100x objective lens), we found that tyrosine phosphorylated proteins are localized in both nucleus and cytoplasm of Sertoli cell as shown in Figure 2A as compared to that of control (Fig.
The retiform pattern is characteristically absent in well-differentiated SLCTs and is diagnosed when a significant portion of the tumor demonstrates networks of anastomosing, slit-like spaces and tubules lined by flattened to cuboidal Sertoli cells in a single layer or stratified pattern [1, 3, 19].
(c and d) Expressions of LIFR and PDGFR[alpha] in pig testes, pig Sertoli cells, pig Spermatogonia stem cells and pig primary isolated SLCs as fold change relative to beta-actin; Spermatogonia, Spermatogonia stem cells.
A two-step enzymatic digestion protocol was used to obtain testicular single-cell suspensions enriched for Sertoli cells [16].
However, in the present study, there was no apparent affection of Sertoli cells. Turner and Miller [47] reported that the severe disruption of Sertoli cells was not a primary feature of testicular I/R injury.
The actin filament bundles were sandwiched between the endoplasmic reticulum (ER) and the TJ strand (black boxed area), which formed the typical structure of basal extracellular specialization (ES) detected on both sides of adjacent Sertoli cells in the rat testis.
The testis tubules show regeneration of the germinal epithelium (15.344 [+ or -] 0.747 [micro]m), due to the activity of the spermatogonia that are grouped in cysts delimited by Sertoli cells, of acidophilic coloration; they have round large nucleus and nucleoli, (103.309 [+ or -] 9.836 [micro]m).
Germ cells migrate between Sertoli cells using the principle of a zipper: in the process of the differentiation and growth of germ cells towards their fate (spermatozoa), the junctions between Sertoli cells open to allow germ cells to migrate, then close again after their passage (Mruk and Cheng, 2004).