In the Sertoli cell tumors expressing neuroendocrine markers and showing morphologic overlap with carcinoid tumor, ER and PR positivity favors Sertoli-stromal cell tumor.
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases.
Immunopanel Positive Inhibin ([dagger]) Inhibin Calretinin ([dagger]) Calretinin Melan-A ([dagger]) Melan-A Vimentin ([dagger]) Vimentin S100 (+/-) Synaptophysin (+/-) Negative Cytokeratin ([dagger]) Cytokeratin AFP ([dagger]) AFP PLAP ([dagger]) PLAP hCG ([dagger]) hCG Sertoli Cell Tumor
Average age 15-85, peaks in age of range, y 45 Characteristic Homogenous, gross features well-circumscribed, mass with grey-white to yellow cut surface.
125) Most Leydig cell tumors, but only a minority of Sertoli cell tumors
, are positive for [alpha]-inhibin and calretinin.
In Carney complex, patients develop upper GI schwannomas or psammomatous melanotic schwannomas in addition to lentigines, nevi, myxomas, pituitary adenomas, large cell calcifying Sertoli cell tumors
, and follicular thyroid lesions.
5) Rare tumors have also been attributed to Peutz-Jeghers syndrome, including testicular sex cord and Sertoli cell tumors
, leading to sexual precocity and gynecomastia, ovarian sex cord tumors with annular tubules, and adenoma malignum of the cervix.
In particular, they summarize key diagnostic features and useful ancillary tools for the most frequently encountered problems in testicular tumor pathology, including the differential diagnoses between seminoma and nonseminomatous germ cell tumors, germ cell tumors and nongerm cell tumors, intratubular germ cell neoplasia and atypical germ cells with maturation arrest, pseudovascular invasion and real lymphovascular invasion in germ cell tumors, and macroscopic Sertoli cell nodules and Sertoli cell tumors