Sertoli cell


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Related to Sertoli cell: Leydig cell, Sertoli cell tumor

Sertoli cell

(sər-tō′lē, sĕr-)
n.
Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.

Sertoli cell

[sertō′lē]
Etymology: Enrico Sertoli, Italian histologist, 1842-1910; L, cella, storeroom
one of the supporting elongated cells of the seminiferous tubules of the testes. It functions to nourish the developing spermatocytes.

Sertoli cell

An elongated cell in the seminiferous tubules of the testis which secretes sex hormone-binding globulin and provides a micro-environment for developing sperm.

Sertoli cells secretions
• Anti-Müllerian hormone—Early foetal life.
• Inhibin and activins—Post-pubertal; regulate FSH secretion.
• Androgen binding protein—Concentrates testosterone in the seminiferous tubules, stimulating spermiogenesis.
• Oestradiol aromatase—Converts testosterone to 17 beta oestradiol for spermatogenesis.
• Glial cell-derived neurotrophic factor—Drives spermatogonial stem cell renewal during perinatal period.
• ERM transcription factor—Maintains spermatogonial stem cell in the adult testis.
• Transferrin—Iron ion delivery.

Sertoli cell

any of the elongated cells in the tubules of the testes to which the spermatids become attached; they provide support, protection and, apparently, nutrition until the spermatids are transformed into mature spermatozoa.

ovarian Sertoli cell tumor
Sertoli-Leydig tumor of an atopic ovary in a bitch, commonly associated with cystic endometrial hyperplasia.
testicular Sertoli cell tumor
occurs most commonly in dogs, particularly in retained testicles. Production of estrogen may cause feminization in which the dog is attractive to other males with reduced libido, feminine distribution of body fat, symmetrical alopecia, atrophy of the penis, increased size of the mammary glands and prepuce, and prostatic enlargement. Rarely there is depression of bone marrow activity with anemia, thrombocytopenia and granulocytopenia.
References in periodicals archive ?
There are numerous extensive reports on the description of the Leydig cells and Sertoli cells and their function in different animal groups (Camatini et al.
Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.
The arrangement of a germinal compartment is explained by its integration with germ and Sertoli cells, and the separation of the germinal and interstitial compartment, both separated by the basement membrane.
Dosedependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis.
Dramatic expansion of germinal stem cells by ectopically expressed human glial cell line-derived neurotrophic factor in mouse Sertoli cells.
Also it was noted in that study the emergence of large gaps (vacuolization) between spermatocytes and this result consistent with what he observed on the vacuolization in the areas between spermatogonia cells and primary spermatocytes or between spermatogonia cells and Sertoli cells, and the cause was in the degeneration and detachment processes which occur in the spermatocytes as a result of drug treatment, and common cold was noted as well in the inflammatory infiltration with the emergence of a rupture and congestion of blood vessels [18; 32; 33].
Spermatogenesis is a multifactor regulated process, where Sertoli cells play a crucial role.
Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow.
MART-1 shows positivity in steroid cell tumors and in the Leydig cells of Sertoli-Leydig cell tumor, but not in the Sertoli cell component.
Cytokines, polarity proteins, and endosomal protein trafficking and signaling--The Sertoli cell blood-testis barrier system in vitro as a study model," Methods in Enzymology 534: 181-194.
Anti-Mullerian hormone (AMH) is a glycoprotein released from the sertoli cells starting from the fetal period.
Cisplatin treatment was found to cause testicular damage due to its harmful attack on spermatogenic cells and Sertoli cells [3, 5-7].