The main characteristic of this stage was the presence of spermatids with elongating nuclei, leading to nuclei of Sertoli cells
. Type A spermatogonia with a similar morphology to those found in the previous stage were also observed at this stage.
Pointis, "Sertoli cell
junctional proteins as early targets for different classes of reproductive toxicants," Reproductive Toxicology, vol.
 reported that I/R injury could cause a loss of testicular testosterone secretion, which might be temporary and defective spermatogenesis induced by intratesticular ROS , stimulating germ cell-specific apoptosis , which is not reported in Sertoli cells
or Leydig cells after testicular torsion repair, although ROS disrupted Leydig cell steroidogenesis through perturbation of the mitochondrial membrane .
Caspase-3 and its activated form of cleaved Caspase-3 were elevated significantly in the three MEHP-treated groups (P < 0.05), while the combination with genistein significantly reduced cleaved Caspase-3 expression although upexpression still existed compared with control (P < 0.05), which further indicates that genistein could partially attenuate Sertoli cell
apoptosis in prepubertal testis, in which process Nrf-2 and downstream HO-1 upregulation may play a vital role in alleviating MEHP-induced oxidative stress.
Caption: Figure 2: Sections from the tumor show networks of anastomosing slit-like to cystic spaces lined by cuboidal Sertoli cells
, resembling the rete testis.
Riccioli, P De Cesaris et al., "Activation of inositol phospholipid turnover and calcium signaling in rat Sertoli cells
by [P.sub.2]-purinergic receptors: modulation of follicle-stimulating hormone responses," Endocrinology, vol.
"The idea is if you could make Sertoli cells
from a skin cell, they'd be accessible for supporting the spermatogenesis process when conducting in vitro fertilization assay or protecting other cell types such as neurons when co-transplanted in vivo," said Whitehead Institute Founding Member Rudolf Jaenisch.
Identification of nuclear triiodothyronine receptors in Sertoli cells
from immature piglet testes.
Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell
number in the neonatal rat.
The research identified that it is the amount of SMAD3 present that controls Sertoli cell
activity prior to, or after, puberty.
A decrease in the sertoli cell
count and absence of the primary stages of the Spermatogenesis were noted.