SERPINE1

(redirected from Serpin E1)

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
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Interestingly, serpin E1 was present in the supernatants of MSC cultured alone, but its presence was significantly increased in MSC cocultured with hepatocytes (Figure 9(b)).
Furthermore, serpin E1 is increasingly detected in coculture conditions with hepatocytes.
(iv) The levels of markers of endothelial and platelet activation (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule1 (sVCAM-1), vascular endothelial growth factor (VEGF), Serpin E1 = plasminogen activator inhibitor-1 (PAI-1), sE-Selectin, and sP-Selectin).
at 4[degrees]C and next stored at -20[degrees]C until analysis of ADMA, SDMA, L-arginine levels, Serpin E1, sP-Selectin, and markers of oxidative stress.
Global Markets Direct's, 'Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1) - Pipeline Review, H1 2016', provides in depth analysis on Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1) targeted pipeline therapeutics.
The report provides comprehensive information on the Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1)
Besides its role in the fibrinolytic system, PAI-1 or serpin E1 plays a role in many human vascular disorders, and recent studies revealed that another serpin, serpin E2 also known as protease nexin-1 (PN-1) phylogenetically relative to PAI-1, is produced by most vascular and blood cells [35].

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