SERPINA10

(redirected from Serpin A10)

SERPINA10

A gene on chromosome 14q32.13 that encodes a member of the serine protease inhibitor (serpin) family which is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid.

Molecular pathology
SERPINA10 mutations are associated with venous thrombosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The analysis studies the alleles of 12 variants located in seven genes (PT, FVL, FXII, FXIII, ABO, SERPIN A10 and SERPIN C1).
In deed some of the polymorphisms (SERPIN A10 and C1) have not been previously tested in RM/RIF.
Our test studied 5 single nucleotide polymorphisms (SNP) with the highest individual odds ratio for venous thrombosis (25) (Factor V Leiden, PT G20210A, A1 blood group, 1 SNP in the Fibrinogen - gene, 1 in the Factor XI gene) as well as some rare genetic variants linked to the thrombosis risk, with stronger effects in the carriers, such as the SERPIN C1 gene (26), the R67X in SERPIN A10 gene (27), or Ser219Gly in the PROCR gene (28).