SERPINA1

(redirected from Serpin A1)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
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References in periodicals archive ?
Serpin A1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the serpin super family of the serine protease inhibitors [12].