SERPINA1

(redirected from Serpin A1)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
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References in periodicals archive ?
Serpin A1 or 1-antitrypsin is included in the serine peptidase inhibitors (Serpins) family which has a very large distribution in the human body and has various functions (coagulation, inflammation, and turnover of extracellular matrix).
Temmel, "The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47," FEBS Letters, vol.
Serpin A1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the serpin super family of the serine protease inhibitors [12].