serpiginous choroidopathy

ser·pig·i·nous cho·roi·dop·a·thy

bilateral acquired abnormality of retinal pigment epithelium and choroid in which irregular multiple progressive swelling is followed by atrophic scars in linear patterns.
An asymmetric maculopathy of middle-aged adults
Diagnosis Fluorescein angiography, early, active lesion has central hypofluorescence with a hyperfluorescent rim; choriocapillaris and retinal pigment epithelium are absent or attenuated in healed lesions making the larger choroidal vessels easily visible clinically and on angiography
Visual field testing Scotomata, densest at the centre
Management Corticosteroids are used, but don’t stop disease progression, long-term combination therapy with prednisone, azathioprine, cyclosporine
DiffDx Multifocal choroiditis; panuveitis; central areolar choroidal sclerosis; sarcoidosis; syphilitic choroiditis; patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), are younger, may have extraocular findings, lesions rarely emanate from optic nerve, acute lesions rarely border inactive scars; age-related macular degeneration; angioid streaks
References in periodicals archive ?
A third patient with Serpiginous Choroidopathy improved from 20/80- to 20/60+1 in the right eye and from 20/50- to 20/20-3 in their left eye with increases in OCT, suggesting value in considering BMSC for atrophic retinal conditions.
Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment.