serotonin transporter


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serotonin transporter (SERT),

a protein, found for example in the terminal of a presynaptic neuron, which decreases the concentration of serotonin near the synapse by effecting its reuptake into the presynaptic neuron.
See also: presynaptic.
References in periodicals archive ?
Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.
Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype.
Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease.
2009) The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon.
Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse.
Another possible explanation for intensity of valence and speed of reaction without reported high arousal is that those who are high in SPS have a higher tonic (general) level of arousal, rather than displaying a greater phasic arousal (change from neutral to high when viewing emotional stimuli), as Canli and Lesch (2007) found for short allele carriers of the serotonin transporter polymorphism (5-HTTLPR).
Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: A [11C] DASB PET study.
Johnson and colleagues (2011) selected the two SLC6A4 functional polymorphisms to personalize ondansetron in the above-mentioned study, because the serotonin transporter is the main modulator of serotonergic signaling.
Finally, there are genetic evidences for the association of a particular polymorphism of the serotonin transporter with alcohol addiction (Feinn, Nellissery & Kranzler, 2005).