selective serotonin reuptake inhibitor

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Related to Serotonin reuptake inhibitors: Effexor, SSRI

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

selective serotonin reuptake inhibitor

a class of chemical compounds that selectively, to varying degrees, inhibit the reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.

selective serotonin reuptake inhibitor

n.
An SSRI.

selective serotonin reuptake inhibitor

Serotonin-selective-reuptake inhibitor, see there.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-ŭp'tāk in-hib'i-tŏr)
A class of drugs that selectively prevent the reuptake of serotonin and are used for the treatment of depression, e.g., fluoxetine, sertraline.

Selective serotonin reuptake inhibitor (SSRI)

A class of antidepressants that work by blocking the reabsorption of serotonin in the brain, raising the levels of serotonin. SSRIs include Prozac, Zoloft, and Paxil.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-up'tāk in-hib'i-tŏr)
Class of chemical compounds that selectively, to varying degrees, inhibit reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.
References in periodicals archive ?
Selective Serotonin Reuptake Inhibitors (SSRIs) are used to treat severe or persistent depression by elevating the extracellular levels of serotonin.
Patients taking anti-depressant medications classified as selective serotonin reuptake inhibitors (SSRIs) are 40 percent more likely to develop severe gastrointestinal bleeding, according to a research review in the Journal of the American Osteopathic Association.
However, the most prescribed classes of drugs in the therapy of depression remain the selective serotonin reuptake inhibitors and the dual reuptake inhibitors of serotonin and norepinephrine, even if part of the data asserts that only 50% of the patients treated with one of these two classes show proof of clinical remission (2).
Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis.
Osteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome [published online ahead of print August 5, 2014], Endocrine.
Among them, citalopram, fluoxetine, and paroxetine belong to selective serotonin reuptake inhibitors (SSRIs), first-line therapeutic agents for treating a wide range of psychiatric disorders such as major depression, generalized anxiety disorder and post-traumatic disorder, to name but a few.
The Question: Does taking selective serotonin reuptake inhibitors (SSRIs), used to treat depression, affect fetal growth during the first year of life?
Tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors (SNRIs) "are our friends" because they treat depression and, unlike selective serotonin reuptake inhibitors, neuropathic pain, as well, he said.
Selective serotonin reuptake inhibitors (SSRIs) are the mainstay of pharmacological treatment for both depression and anxiety disorders.
In addition, a double-blind, placebo-controlled pilot study showed rapid efficacy of ALKS 5461 in 32 patients with major depressive disorder who failed to respond adequately to treatment with selective serotonin reuptake inhibitors (SSRIs) or selective serotonin-norepinephrine reuptake inhibitors (SNRIs), he said.
NORWAY -- Administering proton pump inhibitors (PPIs), which are used to relieve gastroesophageal reflux, together with selective serotonin reuptake inhibitors (SSRIs), which are used to treat depression, has been observed to elevate blood levels of SSRIs by significant amounts.
All had failed to respond adequately to treatment with selective serotonin reuptake inhibitors (SSRIs) or selective serotonin-norepinephrine reuptake inhibitors (SNRIs), he said.

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