serotonin release assay


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Related to serotonin release assay: Heparin induced thrombocytopenia

serotonin release assay

A laboratory test for diagnosing heparin-induced thrombocytopenia. Platelets from a patient suspected of having the disease are mixed with healthy platelets labeled with radioactive serotonin. The release of radiolabeled serotonin after exposure to therapeutic doses of heparin constitutes a positive test.
See also: assay
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To avoid overdiagnosis, confirmatory testing of the patient's serum with a functional assay that detects platelet activation induced by these antibodies, such as the serotonin release assay, is usually required.

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