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A gene on chromosome 17p13 that encodes serine racemase, which converts L-serine to D-serine, a key co-agonist with glutamate at NMDA receptors. It is highly expressed in the hippocampus and corpus callosum.
The activity of serine racemase was inversely regulated by D-serine and NO (25).
This finding also supports the involvement of D-serine in NMDA receptor activation, because D-serine is synthesized from L-serine by serine racemase and glycine has been known to be the precursor of L-serine (2, 3).
Serine racemase protein expression in cortex and hippocampus in schizophrenia.
Capillary electrophoresis method for determination of D-serine and its application for monitoring of serine racemase activity.
In addition, Guilford acquired a proprietary screening system to identify novel inhibitors of serine racemase.
Among other things, there can be no assurance that compounds targeting serine racemase will successfully complete all the preclinical, clinical, regulatory, manufacturing and other steps necessary to develop and commercialize them into safe and effective new drugs.
Nasdaq: GLFD) today announced that it has licensed a discovery from the Johns Hopkins University relating to a unique biological target, serine racemase, that could be used to develop treatments for neurodegenerative diseases.