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A gene on chromosome 17p13 that encodes serine racemase, which converts L-serine to D-serine, a key co-agonist with glutamate at NMDA receptors. It is highly expressed in the hippocampus and corpus callosum.
The activity of serine racemase was inversely regulated by D-serine and NO (25).
This finding also supports the involvement of D-serine in NMDA receptor activation, because D-serine is synthesized from L-serine by serine racemase and glycine has been known to be the precursor of L-serine (2, 3).
Serine racemase protein expression in cortex and hippocampus in schizophrenia.
Capillary electrophoresis method for determination of D-serine and its application for monitoring of serine racemase activity.