TMPRSS3(redirected from Serine protease TADG-12)
Notation for the gene for DFNB10.
TMPRSS3A gene on chromosome 21q22.3 that encodes a putative serine protease which plays a role in hearing, acting as a permissive factor for cochlear hair cell survival and activation at the onset of hearing; it is required for saccular hair cell survival. TMPRSS3 activates the epithelial sodium channel (ENaC). It is also a less preferred gene symbol for what is now designated as TMPRSS4, see there.
Defects in TMPRSS3 cause deafness autosomal recessive types 8 and 10.