SPINK1(redirected from Serine Protease Inhibitor, Kazal Type 1)
Also found in: Acronyms.
SPINK1A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.