PIK3CG

PIK3CG

A gene on chromosome 7q22.3 that encodes the gamma catalytic subunit of phosphoinositide-3-kinase (PI3K), which phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). This gamma catalytic subunit forms a heterodimer with PIK3R5 or PIK3R6 regulatory subunits; its interaction with ADRBK1 through the PIK helical domain is required for targeting to agonist-occupied receptor. It is thought to interact with PDE3B, TPM2 and EPHA8, and to regulate integrin-mediated cell adhesion to substrates.