The first blood test to be commercialized for CRC screening (methylated septin
9 [Epi pro-Colon], Epigenomics, San Diego, California) has such suboptimal performance characteristics that the USPSTF did not include it among its recommended tests, (1) and the USMSTF on CRC flatly recommended against its use.
9 methylated DNA is a sensitive and specific blood test for colorectal cancer.
Mt-sDNA had high sensitivity, similar specificity, and high costs compared with those of FIT alone. In 2016, the first blood-based test, i.e., mSEPT9 assay was evolved, as hypermethylated DNA of septin
9 gene might be shed into the bloodstream from CRC tissues and be detected.
(20) Recently, the Septin
9 serum assay was approved by the US Food and Drug Administration for the screening of adults aged [greater than or equal to]50 years who have been offered, but not completed, CRC screening.
Protein complexes containing Ect2, septin
, and myosin localize at the overlapping zone of microtubules in the equator of the cells (Green et al.
found that the activity of myosin II was reduced by septin
7, which could hinder GLUT4 storage vesicle and fusion with the plasma membrane, reduce glucose uptake into podocytes, and further cause insulin resistance .
Inagaki, "Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin
," Oncogene, vol.
9 amplification and isoform specific expression in peritumoral and tumor breast tissue.
(28.) Ahlquist DA, Taylor WR, Mahoney DW The stool DNA test is more accurate than the plasma septin
9 test in detecting colorectal neoplasia.
9, mutations in cell-free DNA, and several miRNAs extracted from plasma or serum show promising results towards the noninvasive tests for CRC.
(2008) Sensitive detection of colorectal cancer in peripheral blood by septin
9 DNA methylation assay.
These techniques exploit the polarization of light to follow cellular events, from the building of the mitotic spindle to the formation of septin
structures, one molecule at a time.