The Semliki Complex is composed by eight viruses (Bebaru, Chikungunya, Mayaro, Getah, Semliki Forest
, Ross River, O'nyong-nyong, and Una viruses) of veterinary and medical importance, usually causing human disease characterized by fever, arthritis and skin rash (5) (Fig.
When a virus is transmitted by a vector, it can be particularly difficult to confirm or exclude the infectiousness of human cases, as with Semliki forest
, Barmah forest, and Rift Valley fever viruses.
In vitro inhibition of Chikungunya and Semliki Forest
viruses replication by antiviral compounds synergistic effect of interferonalpha and ribavirin combination.
Scientists studied the herpes family of viruses, which can also cause cancer with the Epstein-Barr virus, and the Semliki Forest
virus, which is mainly spread by mosquitoes.
While studying the phylogenetic analysis of chikungunya virus with the sequenced APRa-CTR isolate at nucleotide level with ONN (O'nyongnyong viruses) as an outgroup, inclusion of other representative members of Semliki Forest
(DAK Arbs 6878) and Sindbis-like (Ar Mg 812 and B 448) virus was essential because they were quite distinct from the prototype strain and from all other isolates examined (11).
Human MxA protein confers resistance to Semliki forest
virus and inhibits the amplification of a Semliki forest
virus-based replicon in the absence of viral structural proteins.
El virus Sindbis y el Semliki Forest
Virus (SFV, de sus siglas en ingles; el virus del bosque Semliki, de su traduccion al espanol) son ampliamente conocidos como modelos de estudios a nivel de biologia molecular y celular.
Researchers immunized the mice with recombinant Semliki Forest
virus RNA, which encoded envelope proteins from influenza A virus, RSV, or tickborne encephalitis virus.
gave healthy mice one of five different antimalaria drugs and then injected the animals with either of two tropical viruses -- Semliki Forest
virus or encephalomyocarditis virus.
Alphaviruses: Semliki Forest
Virus and Sindbis Virus as Gene Delivery Vectors
Mayaro virus (MAYV; genus Alphavirus, family Togaviridae) is a single-stranded positive RNA virus that was first isolated in Trinidad in 1954 (1) and is one of the viruses that comprise the Semliki Forest
virus complex (2).
VEEV is of the Alphavirus genus (others include eastern and western equine encephalitis, Chikungunya fever, and Semliki Forest
disease), and was first recognized in the 1930s.