guide the entry of dendritic cells into the lymphatics by activating myosin II.
are guidance proteins which influence cellular morphology and function, and play important roles in organogenesis and disease.
in cancer: biological mechanisms and therapeutic approaches.
2002), and both DPYL proteins and their companion semaphorins
have been reported to be up-regulated in response to nervous system injury (Murphey et al.
Third, two classes of molecular inhibitors to growth are present in the lesioned CNS to actively block axonal growth: inhibitory extracellular matrix proteins, including chondroitin sulfate proteoglycans, and inhibitory proteins present on adult myelin, including Nogo, myelin-associated glycoprotein, oligodendrocyte-myelin glycoprotein, netrin, semaphorins
, Wnt proteins, and others [64-66].
and their receptors in lamprey CNS: cloning, phylogenctic analysis, and developmental changes during metamorphosis.
are a large family of proteins that act as guidance molecules in the developing nervous system.
are embryologically active molecules that regulate nerve growth and direction.
Chemical agents known as suppressins and semaphorins
are being looked at as an adjunct to many other research techniques.
Axons--the long extensions formed by growing brain cells--display neuropilin-1, which reacts to proteins called semaphorins
or collapsins, which serve as axonal stop signs.
are a family of molecules that are repulsive to axonal growth in a number of different species.
Tessier-Lavigne explains that repellent molecules, such as a group known as collapsins or semaphorins
, send a chemical message to axons, saying, "Don't come this way.