selective serotonin reuptake inhibitor

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inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

selective serotonin reuptake inhibitor

a class of chemical compounds that selectively, to varying degrees, inhibit the reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.
Farlex Partner Medical Dictionary © Farlex 2012

selective serotonin reuptake inhibitor

n.
An SSRI.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

selective serotonin reuptake inhibitor

Serotonin-selective-reuptake inhibitor, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-ŭp'tāk in-hib'i-tŏr)
A class of drugs that selectively prevent the reuptake of serotonin and are used for the treatment of depression, e.g., fluoxetine, sertraline.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Selective serotonin reuptake inhibitor (SSRI)

A class of antidepressants that work by blocking the reabsorption of serotonin in the brain, raising the levels of serotonin. SSRIs include Prozac, Zoloft, and Paxil.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-up'tāk in-hib'i-tŏr)
Class of chemical compounds that selectively, to varying degrees, inhibit reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Seroxat, known as a selective serotonin re-uptake inhibitor (SSRI), is the world's best selling anti-depressant and is used to treat millions of patients worldwide who are also suffering from anxiety, post traumatic stress, panic attacks and obsessive compulsive disorders.
Selective serotonin re-uptake inhibitors (SSRIs) have been used for treatment of anxiety and depression [3].
Commonly prescribed medications for GAD include benzodiazepines and antidepressants such as selective serotonin re-uptake inhibitors, and whilst effective, they can be associated with adverse side effects.
Low levels of central serotonin have been related to the state of depression, and 5-HT is the major target of newer antidepressant drugs, such as selective serotonin re-uptake inhibitors. Neurons and platelets display structural and functional similarities, so that the latter have been proposed as a peripheral model of central functions.
Reports have surfaced on the deleterious effects of two commonly used drugs on a developing baby - paracetamol and antidepressant SSRIs (Selective serotonin re-uptake inhibitors).
Emma, by email A Taking antidepressants such as Prozac and other SSRIs (selective serotonin re-uptake inhibitors) can affect your sex drive and make people feel Have your emotional problems sorted by our expert Marisa switched off from their emotions.
GBI Research, the leading business intelligence provider, has released its latest research, Antidepressants Market to 2018 Despite Safety Concerns, Selective Serotonin Re-uptake Inhibitors (SSRIs) Continue to Dominate in the Absence of Effective Therapeutic Alternatives, which provides insights into the antidepressants market until 2018.
Serotonin is the target of the popular antidepressants known as SSRIs, or selective serotonin re-uptake inhibitors, which prolong the effect of serotonin in the brain by slowing its absorption by brain cells.
A comparison of the post-marketing safety of four selective serotonin re-uptake inhibitors including the investigation of symptoms occurring on withdrawal.
Newer "selective serotonin re-uptake inhibitors" - including Prozac - rose by 5.6 per cent in the last year.
(5) However, despite some support through the efficacy of such medications as tricyclic antidepressants (TCA) and selective serotonin re-uptake inhibitors (SSRIs), this theory remains at best incomplete.

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