selective progesterone receptor modulator

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selective progesterone receptor modulator



A class of medications that attach to cellular binding sites for the hormone progesterone, and either stimulate those sites, block them, or both block and stimulate them. They have a variety of uses in obstetrics and gynecology. Antagonist (blocking) agents like mifepristone can induce abortion. Agonist (receptor-stimulating) drugs may be used to treat uterine fibroids.
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References in periodicals archive ?
Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications.
The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator in healthy premenopausal women.
Therapeutic potential for the selective progesterone receptor modulator asoprisnil in the treatment of leiomyomata.
Biochemical, pharmacological and clinical studies have led to synthesizing progesterone receptor antagonists (PRAs) and selective progesterone receptor modulators (SPRMs) during the last two decades.
As a selective progesterone receptor modulator, asoprisnil has an agonist/antagonist effect on progesterone receptors, with high tissue selectivity.
The company said FIBRISTAL belongs to a class of medications called selective progesterone receptor modulators (SPRMs).
Future therapies include selective progesterone receptor modulators such as asoprisnil, which induce amenorrhea without side effects of hypoestrogenism and control uterine prostaglandins.

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