selective estrogen receptor modulator

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Related to Selective estrogen receptor modulators: raloxifene, Aromatase inhibitors

modulator

 [mod´u-la″ter]
a specific inductor or agent that brings out characteristics peculiar to a definite region.
selective estrogen receptor modulator (SERM) an agent that activates some estrogen receptors but not others, thereby having estrogenlike effects on target tissues (such as bone) without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator (SERM),

pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

selective estrogen receptor modulator

n.
Abbr. SERM Any of a group of nonsteroidal drugs, such as raloxifene and tamoxifen, that bind to estrogen receptors and act in some cases as estrogen agonists and in others as estrogen antagonists.

selective estrogen receptor modulator (SERM)

an agent that activates some estrogen receptors but not others, thereby having estrogen-like effects on target tissues without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator

Designer estrogen, SERM Therapeutics A drug–eg, idoxifene, raloxifene–Evista®, which, like estrogen, prevents bone loss and ↓ cholesterol but, unlike estrogen, does not stimulate the endometrium and breast and thus does not ↑ risk of breast and endometrial CA. See Estrogen receptor, Raloxifene.

se·lec·tive es·tro·gen re·cep·tor mod·u·la·tor

(SERM) (sĕ-lek'tiv es'trŏ-jen rĕ-sep'tŏr mod'yū-lā'tŏr)
Pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

Selective estrogen receptor modulator

A hormonal preparation that offers the beneficial effects of hormone replacement therapy without the increased risk of breast and uterine cancer associated with HRT.
Mentioned in: Osteoporosis
References in periodicals archive ?
Supply of consumables workshop of the project "development of new selective estrogen receptor modulators to treat the effects of menopause"
Many companies hope to develop a designer estrogen, or selective estrogen receptor modulator (SERM), that men can take to prevent heart disease.
Clinically, bisphosphonates, parathyroid hormones, selective estrogen receptor modulators and activated vitamin D and analogues are used most often, which is the same as the situation in China.
Both drugs are selective estrogen receptor modulators.
Abstract: Because of recent concerns about the long-term risks of estrogen replacement therapy in postmenopausual women, there is growing interest in a group of compounds known as selective estrogen receptor modulators (SERMs).
In 1998, the FDA approved Evista (raloxifene hydrochloride), the first in a new class of drugs called selective estrogen receptor modulators (SERMs).
Pipeline Analysis & Forecasts: Selective Estrogen Receptor Modulators
NASDAQ: BNVI), a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, today announced the publication of a study on the effects of two botanically-derived, tissue selective estrogen receptor modulators for the treatment of postmenopausal obesity in the Journal of the Public Library of Science One.
Because selective estrogen receptor modulators (SERMs) have beneficial effects other than bone building, they may be an attractive alternative treatment for osteoporosis, Dr.
Estrogens and selective estrogen receptor modulators, such as raloxifene, are under investigation and may be particularly useful for men who are undergoing prostate cancer treatment and who can't take androgens.
The present Competitive Intelligence Report about Selective Estrogen Receptor Modulators (SERM) provides a competitor evaluation in the field of small molecules selectively modulating estrogen receptor (SERM) as of January 2010.
The grant will fund the first phase in a planned multi-phase study to evaluate Bionovo's plant derived tissue selective estrogen receptor modulators for preventing obesity and the metabolic syndrome.

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