selective estrogen receptor modulator

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Related to Selective estrogen receptor modulators: raloxifene, Aromatase inhibitors

modulator

 [mod´u-la″ter]
a specific inductor or agent that brings out characteristics peculiar to a definite region.
selective estrogen receptor modulator (SERM) an agent that activates some estrogen receptors but not others, thereby having estrogenlike effects on target tissues (such as bone) without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator (SERM),

pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

selective estrogen receptor modulator

n.
Abbr. SERM Any of a group of nonsteroidal drugs, such as raloxifene and tamoxifen, that bind to estrogen receptors and act in some cases as estrogen agonists and in others as estrogen antagonists.

selective estrogen receptor modulator (SERM)

an agent that activates some estrogen receptors but not others, thereby having estrogen-like effects on target tissues without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator

Designer estrogen, SERM Therapeutics A drug–eg, idoxifene, raloxifene–Evista®, which, like estrogen, prevents bone loss and ↓ cholesterol but, unlike estrogen, does not stimulate the endometrium and breast and thus does not ↑ risk of breast and endometrial CA. See Estrogen receptor, Raloxifene.

se·lec·tive es·tro·gen re·cep·tor mod·u·la·tor

(SERM) (sĕ-lek'tiv es'trŏ-jen rĕ-sep'tŏr mod'yū-lā'tŏr)
Pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

Selective estrogen receptor modulator

A hormonal preparation that offers the beneficial effects of hormone replacement therapy without the increased risk of breast and uterine cancer associated with HRT.
Mentioned in: Osteoporosis
References in periodicals archive ?
Selective estrogen receptor modulators (SERMs) are a good treatment option for younger patients at an increased risk for fractures, who have to take the long-term therapy, and for the patients without a risk for thrombosis, but who have contraindications for other treatments [28].
Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy.
Supply of consumables workshop of the project "development of new selective estrogen receptor modulators to treat the effects of menopause"
Both drugs are selective estrogen receptor modulators, or SERMS, which block estrogen from locking onto receptors on cancer cells, but acts as estrogen elsewhere in the body, including bones.
Sometimes referred to as 'designer estrogens', the FDA has approved selective Estrogen Receptor Modulators (SERM) for the treatment and prevention of osteoporosis.
The selective estrogen receptor modulators, or SERMS, are a new class of synthetic estrogens that act like estrogen in certain parts of the body (such as the bones) while leaving other parts of the body unaffected.
Type of Selective Estrogen Receptor Modulators (SERMs) developed to provide beneficial effects but not disadvantages of estrogen.
Other scientists are less willing to give ER-beta a role in the actions of designer estrogens, which are also called selective estrogen receptor modulators, or SERMS.
The search for an ideal estrogen agonist/antagonist agent has led to the generation of selective estrogen receptor modulators (SERMs).
HONOLULU -- Uses for selective estrogen receptor modulators have grown beyond prevention of breast cancer or osteoporosis to treatment of postmenopausal symptoms.

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