secretory component

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Related to secretory component: immunoglobulin M, secretory IgA

se·cre·to·ry com·po·nent

a polypeptide chain found in external secretions (for example, tears, saliva, colostrum) associated with immunoglobulins A and M. It also may occur in free form but when attached to dimeric IgA, it facilitates transport across the mucosal epithelial surface. The secretory piece is derived by proteolytic cleavage of the immunoglobulin receptor on epithelial cells.

secretory component

a glycopeptide that is attached to immunoglobulin A (IgA). It is necessary for the secretion of IgA into mucosal spaces.


pertaining to secretion.

secretory cells
the specialized cells in a secretory gland that perform the secretory function.
secretory component
a polypeptide synthesized by epithelial cells that binds to IgA to form secretory IgA (SIgA).
secretory diarrhea
see secretory diarrhea.
secretory endpieces
secretory granules
intracellular granules composed of secretory proteins after their conversion by the Golgi apparatus.
secretory IgA (SIgA)
a class of immunoglobulin found in some body secretions, e.g. saliva, respiratory secretions, milk and colostrum, that is responsible for local immunity. See also immunoglobulin.
References in periodicals archive ?
Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces.
Free secretory component and lactoferrin of human milk inhibit the adhesion of enterotoxigenic Escherichia coli.
Both the free form of secretory component and its antibody-bound version can inhibit the binding of the toxin to intestinal cells, apparently by latching onto the toxin itself, says Dallas.