secretory component

(redirected from Secretory chain)

se·cre·to·ry com·po·nent

a polypeptide chain found in external secretions (for example, tears, saliva, colostrum) associated with immunoglobulins A and M. It also may occur in free form but when attached to dimeric IgA, it facilitates transport across the mucosal epithelial surface. The secretory piece is derived by proteolytic cleavage of the immunoglobulin receptor on epithelial cells.
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References in periodicals archive ?
Salivary IgA anti-htTG activity was analyzed for the IgA secretory chain by use of a monoclonal antibody.
The secretory form of salivary IgA anti-htTG was assayed by ELISA with a monoclonal anti-human IgA secretory chain antibody (cat.
All six saliva specimens selected with different values of anti-htTG (range, 25-65%) displayed the IgA secretory chain, whereas all serum samples tested negative.