secretory component

(redirected from Secretory chain)

se·cre·to·ry com·po·nent

a polypeptide chain found in external secretions (for example, tears, saliva, colostrum) associated with immunoglobulins A and M. It also may occur in free form but when attached to dimeric IgA, it facilitates transport across the mucosal epithelial surface. The secretory piece is derived by proteolytic cleavage of the immunoglobulin receptor on epithelial cells.

secretory component

a glycopeptide that is attached to immunoglobulin A (IgA). It is necessary for the secretion of IgA into mucosal spaces.


pertaining to secretion.

secretory cells
the specialized cells in a secretory gland that perform the secretory function.
secretory component
a polypeptide synthesized by epithelial cells that binds to IgA to form secretory IgA (SIgA).
secretory diarrhea
see secretory diarrhea.
secretory endpieces
secretory granules
intracellular granules composed of secretory proteins after their conversion by the Golgi apparatus.
secretory IgA (SIgA)
a class of immunoglobulin found in some body secretions, e.g. saliva, respiratory secretions, milk and colostrum, that is responsible for local immunity. See also immunoglobulin.
References in periodicals archive ?
Salivary IgA anti-htTG activity was analyzed for the IgA secretory chain by use of a monoclonal antibody.
The secretory form of salivary IgA anti-htTG was assayed by ELISA with a monoclonal anti-human IgA secretory chain antibody (cat.
All six saliva specimens selected with different values of anti-htTG (range, 25-65%) displayed the IgA secretory chain, whereas all serum samples tested negative.