Clara cell secretory protein of 10-16 kDa (CC16), also known as CC10, Club cell protein, CCSP, or uteroglobin [9,10], a member of the secretoglobin
family , is the most abundant protein in bronchoalveolar lavage (BAL) fluid or tracheal aspirates (TA) from neonates [12,13].
protein, as a sort of CCSPs, has anti-inflammatory properties.
Genes such as EpCAM, cadherin 1_1 (CDH1_1), secretoglobin
family 2A member 1 (SCGB2A1)/MAM, estrogen receptor 1 (ESR1), epithelial membrane protein 2 (EMP2), and KRT19 were exclusively expressed in CTCs, while protein tyrosine phosphatase, receptor type C (PTPRC; formerly called CD45) and vimentin (VIM) were predominant in the leukocytes.
(SCGB) 3A2 belongs to the SCGB gene superfamily of cytokine-like secretory proteins of small molecular weight (~10kDa) [1-3].
Chilton, "Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin
superfamily," Endocrine Reviews, vol.
showed that a panel of 6 genes was superior to EpCAM and secretoglobin
, family 2A, member 2 (SCGB2A2, also known as mammaglobin and hMAM) for the detection of CTCs in breast cancer, and that theses genes may serve as potential markers for CTC derived from endometrial, cervical, and ovarian cancers as well (40).
By using a multimarker assay for CTC in early breast cancer, we have shown that CTCs positive for KRT19 (keratin 19; also known as CK19), SCGB2A2 (secretoglobin
, family 2A, member 2; also known as MGB1, mammaglobin A), and ERBB2 are associated with shorter disease-free survival (6).
The crystal structure of the major eat allergen Fel d 1, a member of the secretoglobin
Other multipotent stem cells in the lungs include variant club cells, positive for secretoglobin
family 1a member 1 (Scgb1a1) and Cyp2f2-negative.
Cigarette smoke induces mucous cell hyperplasia and mucus hypersecretion contributing to airway obstruction; in the small airways, smoking-induced goblet cell hyperplasia is associated with loss of club cells, responsible for the production of secretoglobin
, surfactant protein, and other defense factors .
1A1 and 1A1A differentially regulate neutrophil reactive oxygen species production, phagocytosis and extracellular trap formation.
Sato et al., "Secretoglobin
3A2 attenuates lipopolysaccharide-induced inflammation through inhibition of ERK and JNK pathways in bronchial epithelial cells," Inflammation, vol.