Beta-adrenergic stimulation, via cyclic AMP second messenger systems
, increases cellular metabolism and enzymatic secretions.
An initial neurotransmitter will activate the fast ion channel receptor, while a second or third neurotransmitter will activate the second messenger system that modifies the effect of the initial transmitter.
It is the second messenger system that can modify the postsynaptic potential of the neurotransmitter, enhancing the potential of the response, inhibiting further release of the NT or terminating the postsynaptic response.
This results in partnering of two genes, namely BCR and ABL (which encode a tyrosine kinase involved in second messenger systems
controlling growth and proliferation.) The resultant fusion protein, BCR-ABL represents an unregulated, permanently switched on tyrosine kinase responsible for phosphorylating tyrosine residues on a number of downstream proteins.
While some sections focus on cutting edge areas of science such as 'Mechanisims of anaesthesia: a role for voltage-gated K channels?' or 'Nanotechnology', the majority offer straightforward clear synopses of areas of basic physiology and pharmacology such as acid-base balance, temperature regulation, receptors and second messenger systems
. The section on chirality is particularly well written and covers this important area in considerably more detail than that found in most other pharmacology or anaesthesia texts.