minocycline hydrochloride

(redirected from Sebren)

minocycline hydrochloride

Aknemin (UK), Dentomycin (UK), Dom-Minocycline (CA), Dynacin, Gen-Minocycline (CA), Minocin, Novo-Minocycline (CA), PMS-Minocycline (CA), Ratio-Minocycline (CA), Riva-Minocycline (CA), Sandoz Minocycline (CA), Sebomin (UK), Sebren (UK), Solodyn

Pharmacologic class: Tetracycline

Therapeutic class: Anti-infective

Pregnancy risk category D


Binds reversibly to 30S ribosome, inhibiting bacterial protein synthesis


Capsules: 50 mg, 75 mg, 100 mg

Capsules (pellet-filled): 50 mg, 100 mg

Microspheres (sustained-release): 1 mg

Suspension: 50 mg/5 ml

Tablets: 50 mg, 75 mg, 100 mg

Indications and dosages

Infections caused by susceptible organisms

Adults: Initially, 200 mg P.O. then 100 mg P.O. q 12 hours or 50 mg P.O. q 6 hours

Children ages 8 and older: 4 mg/kg P.O. followed by 2 mg/kg q 12 hours

Gonorrhea in penicillin-sensitive patients

Adults: Initially, 200 mg P.O., then 100 mg q 12 hours for at least 4 days

Uncomplicated gonococcal urethritis in men

Adults: 100 mg P.O. q 12 hours for 5 days


Adults: Initially, 200 mg P.O., then 100 mg q 12 hours for 10 to 15 days


Adults: 50 mg P.O. one to three times daily

Dosage adjustment

• Renal impairment


• Hypersensitivity to drug, its components, or tetracyclines


Use cautiously in:

• sulfite sensitivity, renal disease, hepatic impairment, nephrogenic diabetes insipidus

• cachectic or debilitated patients

• pregnant (last half of pregnancy) or breastfeeding patients

• children younger than age 8 (not recommended).


• Ask patient about sulfite sensitivity before giving.

• Give with 8 oz. of water, with or without food.

• Know that drug is used in penicillin-sensitive patients.

Adverse reactions

CNS: headache

CV: pericarditis

EENT: pharyngitis

GI: nausea, vomiting, diarrhea, oral candidiasis, stomatitis, mouth ulcers

GU: bladder or vaginal yeast infection

Metabolic: eosinophilia, hemolytic anemia, thrombocytopenia

Skin: photosensitivity, rash

Other: dental caries; dental infection; gingivitis; periodontitis; tooth disorder, pain, or discoloration; superinfection; hypersensitivity reactions including anaphylaxis


Drug-drug. Adsorbent antidiarrheals: decreased minocycline absorption

Antacids containing aluminum, calcium, or magnesium; calcium, iron, and magnesium supplements; sodium bicarbonate: decreased minocycline absorption

Cholestyramine, colestipol: decreased oral absorption of minocycline

Hormonal contraceptives: decreased contraceptive efficacy

Methoxyflurane: nephrotoxicity

Penicillin: interference with bactericidal action of penicillin

Sucralfate: blocked absorption of minocycline

Warfarin: increased anticoagulant effect

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, amylase, aspartate aminotransferase, bilirubin, blood urea nitrogen: increased levels

Hemoglobin, platelets, neutrophils, white blood cells: decreased levels

Urinary catecholamines: false elevation

Drug-food. Dairy products: decreased minocycline absorption

Drug-behaviors. Alcohol use: decreased antibiotic effect

Sun exposure: increased risk of photosensitivity reaction

Patient monitoring

• Assess patient's oral health closely for dental problems.

• Monitor patient for superinfection, especially oral, bladder, and vaginal yeast infections.

• Evaluate CBC and renal and liver function tests frequently.

Watch closely for hypersensitivity reactions, including anaphylaxis.

Patient teaching

• Tell patient he may take with or without food, followed by a full glass of water. Instruct him to space doses evenly over 24 hours and to take one dose 1 hour before bedtime.

• Advise patient not to take with antacids or iron, calcium, or magnesium products.

Instruct patient to immediately report fever, chills, skin rash, unusual bleeding or bruising, sore throat, or mouth pain or discomfort.

• Stress importance of good oral hygiene to minimize adverse oral and dental effects.

• Tell patient to complete entire course of therapy even after symptoms improve.

Caution patient not to use outdated minocycline because it may cause serious kidney disease.

• Inform female patient that drug may make hormonal contraceptives ineffective. Urge her to use barrier contraception.

• Tell pregnant patient that drug may stain fetus' teeth if taken during last half of pregnancy.

• Advise female patient to tell prescriber if she is breastfeeding.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

minocycline hydrochloride

An antibiotic of the tetracycline class. It is used in dentistry to treat periodontal disease. Minocycline is applied after scaling and root debridement. The application reduces probing depths and periodontal pathogenic microorganisms.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The show was directed by David Sebren and the scenic design was done by Jason Strom.
The effectiveness of this tool was immediately apparent and gave Sebren a first-hand look at the set in full scale.
ESPN's Kimberly Elchlepp said the network doesn't disclose financial details.<br />With the growth of the WCWS, the NCAA requested that USA Softball, which owns and operates the stadium, update the complex in order to make sure it can stay the home of the event for the long term, USA Softball National Teams Director Chris Sebren said.<br />The Hall of Fame Complex has been undergoing a face-change for the past few years.
Mike Sebren has been hired as senior project manager for intertek-PSI in Little Rock.
Byline: Dara James, Ann Sebren, Cheryl DerAnanian, Meg Bruening, Laura Rooney, Teresa Araas and Pamela D.
"As consumers become more environmentally conscious, they are aware of the need to find products that reduce energy consumption in a safe, cost-efficient manner," said James Sebren, managing member of Insul-Green, LLC.
(AP) -- Beginning next year, a lot of Louisiana high school classrooms could look like Wes Sebren's: equipped with welding gear, safety goggles and circular saws.
Sebren, a teacher at West Ouachita High School near West Monroe, is at the forefront of public schools' response to a 2009 law passed by the Legislature that encourages teaching skills that students will need in the work-force.
Senior Woodwind: Curtis Sebren, Arkansas; Kelly Johnson, teacher
Since Shulman (1986) proposed a conceptual framework of knowledge base for effective teaching, developing preservice teachers' pedagogical content knowledge has received substantial attention among researchers and teacher educators in physical education (Ennis, 1991 ; Graber, 1995; Rovegno, 1992, 1993a, 1993b, 1998; Sebren, 1995).
Researchers in physical education have begun investigating the development of preservice and inservice teachers' pedagogical content knowledge within a specific context of teacher education programs that have adopted movement approaches to teaching elementary physical education (Ennis, 1991; Rovegno, 1992, 1993a, 1993b, 1998; Sebren, 1995).