CXCL12

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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
This variable highly correlated (absolute value > 0.15) with IDH1 (0.60), TLR8 (0.33), ZNRD1 (0.32), TRIM5a (0.26), IRF1 (0.23), PROX1 (0.23), Slurp1 (0.21), HLA-C (0.21), GML (0.21), CUL5 (0.19), CXCR1 (0.17), TSG101 (0.17), APOBEC3B (0.15), TLR4 (-0.15), DCSIGN (-0.17), SDF1 (-0.26), HLA-B (-0.41), MYH9 (-0.49), PPIA (-0.54), and NCOR2 (-1.10).
Golden, "SDF1 regulates leading process branching and speed of migrating interneurons," The Journal of Neuroscience, vol.
SDF1 also induced two other important structural changes.
One of the cells composing these HSPC niche is mesenchymal stem cells (MSCs) which control important functions of HSPCs through direct cell-to-cell contacts, the formation of an extracellular matrix network, and secretion or suppression of endogenous cytokines and factor such as C-X-C motif chemokine 12 (CXCL12, also known as stromal cell-derived factor 1, SDF1), SCF, angiopoietin 1 (ANGPT1), vascular cell adhesion molecule 1 (VCAM1), and TPO [8-10].
established an ABM model using the Markov Chain Monte Carlo approach to simulate the effects of SDF1 induced chemophysical communications among MICs and BMSCs on myeloma cell growth and examine whether the biophysical properties of myeloma niches are druggable with two representative drugs [96].
Moreover, significant differences in SDF1 levels were observed between Class I and Class IV (P = 0.013), Class I and Class V (P = 0.002), Class II and Class IV (P = 0.015), and Class II and Class V (P = 0.009) patients (Figure 3(a)).
Researchers injected one of three doses of the SDF1 gene(5mg, 15mgor30mg) into the hearts of 17 patients with symptomatic heart failure and monitored them for up to a year.
It was demonstrated that CD4 T cells also secrete MIP1[alpha], MIP1[beta] and RANTES that protect it against R5 strain of HIV-1, and SDF1 protects it against the X4 strain of HIV-1 (23).
A third chemokine, stromal cell-derived factor-1 (SDF1), seems to be important in breast cancer progression and was demonstrated to be overproduced in breast cancer tissue (23-27).
These include the inhibition of glucagon-like peptide 1 (GLP1) and stromal cell-derived factor 1 (SDF1) degradation.
Stromal-derived factor (SDF1, also known as pre-B-cell growth-stimulating factor) is the natural ligand for the chemokine receptor CXCR4.