lymphoepithelioma

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lymphoepithelioma

/lym·pho·epi·the·li·o·ma/ (lim″fo-ep″ĭ-thēl″e-o´mah) a pleomorphic, poorly differentiated carcinoma arising from modified epithelium overlying lymphoid tissue of the nasopharynx.

lymphoepithelioma

[lim′fō·ep′ithē′lē·ō′mə]
Etymology: L, lympha + Gk, epi, above, thele, nipple, oma, tumor
a poorly differentiated neoplasm developing from the epithelium overlying lymphoid tissue in the nasopharynx. It occurs most frequently in young people of Asian origin. Also called lymphoepithelial carcinoma.

nasopharyngeal carcinoma

A rare (in the West) malignancy which is endemic in regions of southern China—where it comprises up to 18% of cancers—as well as in southeast Asia. It is linked to EBV infection, diets high in nitrosamines and inhaled carcinogens. It is more common in males and has a peak incidence of age 40 to 50.

DiffDx
Lymphoma (DLCBL, Hodgkin's), reactive lymphoid proliferation, sarcomas.

Management
Radiotherapy, chemotherapy.

Prognosis
Stage dependant; 5-year survival is 55%.

Nasopharyngeal carcinomas (WHO, 2005)
- Keratinising squamous cell carcinoma
- Non keratinsing carcinoma
  • Differentiated
  • Undifferentiated
- Basaloid squamous cell carcinoma
- Nasopharyngeal cancer, staging
  • Stage I—Lesion confined to nasopharynx.
  • Stage II
    A) Lesion extends to oropharynx and/or nasal fossa.
    B) Lesion extends to nearby lymph nodes or to parapharyngeal region.
  • Stage III—Lesion spread to lymph nodes on both sides of the neck or nearby bones or sinuses.
  • Stage IV
    A) Spread beyond nasopharynx to other areas in head; possible spread to regional lymph nodes.
    B) Spread beyond nasopharynx to other areas in head and to lymph nodes above clavicle, or are ≥ 6 cm in greatest dimension.
    C) Metastasised.

lymphoepithelioma

Undifferentiated nasopharyngeal carcinoma A CA with a marked lymphocytic component Types–Schmincke type Diffuse mixing of epithelial and lymphoid elements, making the lesion difficult to distinguish from lymphoma, since the epithelial cells may mimic lymphoblasts or the lacunar cell variants of Reed-Sternberg cells Regaud type Cohesive carcinoma cell aggregates that are large enough to make the epithelial nature of the tumor obvious Diagnosis Immunoperoxidase stains for cytokeratin

lym·pho·ep·i·the·li·o·ma

(lim'fō-ep'i-thē'lē-ō'mă)
A poorly differentiated radiosensitive squamous cell carcinoma involving lymphoid tissue in the region of the tonsils and nasopharynx; metastasizes early to cervical lymph nodes.
[lympho- + epithelium + -oma, tumor]

Schmincke,

Alexander, German pathologist, 1877-1953.
Schmincke tumor - Synonym(s): lymphoepithelioma

lym·pho·ep·i·the·li·o·ma

(lim'fō-ep'i-thē'lē-ō'mă)
A poorly differentiated radiosensitive squamous cell carcinoma involving lymphoid tissue in the region of the tonsils and nasopharynx; metastasizes early to cervical lymph nodes.
[lympho- + epithelium + -oma, tumor]

lymphoepithelioma (lim´fōep´i-thē´lēō´mə),

n a malignant neoplasm arising from the epithelium and lymphoid tissue of the nasopharynx and characterized by cells of both tissues; may occur in the palate.