Shindler, M.D., Ph.D., an associate professor of Ophthalmology in the Perelman School of Medicine at the University of Pennsylvania and Penn's Scheie
Eye Institute, and senior author on the paper continued, "In this study we demonstrated the ability of ST266 to confer longer-term neuroprotective effects, by showing that EAE mice that received either once or twice daily intranasal drops of ST266 starting from day 15 and repeated through day 56 showed significant preservation of vision, significant preservation of retinal ganglion cells, and significant reduction in optic nerve inflammation."
Cideciyan, Ph.D., who was one of the co-investigators at the Scheie
Eye Institute of the University of Pennsylvania.
Hasseleid BF, Meling TR, Ronning P, Scheie
D, Helseth E.
Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA
Yazdankhah SP, Scheie
AA, H0iby EA, Lunestad BT, Heir E, Fotland T0;, et al.
Tylki-Szymanska, "Enzyme replacement therapy in an attenuated case of mucopolysaccharidosis type I (scheie
syndrome): a 6.5-year detailed follow-up," Pediatric Neurology, vol.
Eye Institute and FM Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
TM pigmentation was graded according to Scheie
's grading system.