In the salt-sugar additive group, the number of species and the relative abundance of molds and yeasts, such as Pseudallescheria, Cladorrhinum, and Scedosporium
, began to increase.
and Aspergillus spp., including multi-drug resistant strains including Candida auris and rare, hard-to-treat moulds including Fusarium spp., Scedosporium
spp., and fungi from the Mucorales order.
Voriconazole (VRZ) ((2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butan-2-ol) is a novel broad spectrum triazole antifungal agent for the treatment of serious infections caused by Aspergillus, Fusarium, Scedosporium
, and resistant Candida species.
The indications for susceptibility testing are rare and include clinical failure or infection with pathogens known to be resistant to AmB like Candida lusitaniae, Trichosporon spp., Fusarium spp., Pseudallescheria boydii (asexual form Scedosporium
Gao, "Effects of Photodynamic Therapy on the Growth and Antifungal Susceptibility of Scedosporium
and Lomentospora spp," Mycopathologia, vol.
The prolonged intake of voriconazole for the treatment of Scedosporium
apiospermum was observed in 2 patients.
krusei, dimorphic fungi, opportunistic molds like Aspergillus spp., and amphotericin-B-resistant Aspergillus terreus, Fusarium spp., and Scedosporium
Voriconazole is currently labeled by the United States Food and Drug Administration (FDA) for invasive aspergillosis and salvage therapy for Scedosporium
and Fusarium infections in humans.
Members of the genus Pseudallescheria, producing Scedosporium
and eventually Graphium synanamorphs, are frequently found in subcutaneous and systemic infections.
Among the isolates Aspergillus species formed 67% and the remaining 33% was found by Geotrichum, Scedosporium
, and Apophysomyces species equally.