(redirected from Sames)
Also found in: Dictionary, Thesaurus, Legal, Acronyms, Idioms, Encyclopedia, Wikipedia.
Related to Sames: games, Samis


(sam-ee) ,


(trade name),


(trade name), (trade name)


Therapeutic: antidepressants
Pregnancy Category: UK
Treatment of depressionHas also been used to manage:
  • osteoarthritis
  • fibromyalgia
  • liver disease
  • migraine headaches


May aid in the production, activation, and metabolism of various amines, phospholipids, hormones, and neurotransmitters. May stimulate articular cartilage growth and repair.

Therapeutic effects

Decreased depression.
Anti-inflammatory and analgesic effects improve symptoms of osteoarthritis.


Absorption: Rapidly and extensively metabolized following oral administration.
Distribution: Unknown.
Metabolism and Excretion: Actively metabolized by the liver.
Half-life: 100 min.

Time/action profile (antidepressant action)

PO (depression)1–2 wkunknownunknown
PO (osteoarthritis)30 daysunknownunknown


Contraindicated in: Hypersensitivity; Bipolar disorder.
Use Cautiously in: Pregnancy, lactation, or children (safety not established); Bipolar disorder (can induce mania); Parkinson's disease (may worsen symptoms); Surgery (discontinue 2 weeks prior to elective procedures).

Adverse Reactions/Side Effects

Central nervous system

  • agitation
  • dizziness
  • mild insomnia
  • manic reactions (in patients with bipolar disorder)


  • vomiting
  • diarrhea
  • flatulence


Avoid use with antidepressants, meperidine, pentazocine, tramadol, and dextromethorphan (additive serotinergic effects may occur).May ↓ effectiveness of levodopa and worsen Parkinsonian symptoms.Should not be used concurrently with MAO inhibitors. Avoid use of SAMe within 2 wk of using a MAO inhibitor.Avoid use with natural products that increase serotonin levels such as l-tryptophan and St. John's wort.
Oral (Adults) Depression—200 mg once or twice daily, adjusted upward over 2 wk (range 400–1600 mg/day); Liver disorders—1200–1600 mg/day; Osteoarthritis—200 mg tid; Fibromyalgia—800 mg/day.


Tablets: 100 mg, 200 mg, 400 mgOTC

Nursing implications

Nursing assessment

  • Assess mental status for symptoms of depression prior to and periodically during therapy; advise patients with depression to be evaluated by a health care professional.
  • Assess symptoms of pain and fatigue prior to and periodically during therapy.

Potential Nursing Diagnoses

Ineffective coping (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Oral: Administer on an empty stomach. Initial dose should be 200 mg once or twice daily to minimize GI disturbances. Dose may be adjusted upward over 1–2 wks depending on response and tolerance.

Patient/Family Teaching

  • Instruct patient to take SAMe as directed.
  • Advise patients to discontinue 2 weeks prior to elective surgical procedures.
  • Advise women to consult health care professional if pregnancy is planned or suspected or if breast feeding.

Evaluation/Desired Outcomes

  • Decrease in symptoms of depression.
  • Improvement in osteoarthritis symptoms.
References in periodicals archive ?
For the purposes of this study, however, it seems more sensible to focus precisely on the four fundamental terms of self other, same, and different.
Improved surface smoothness was achieved while maintaining the same level of sag resistance at equal or increased spray solids.
Perhaps restore [ina/ana A]N-e, ina/ana same, at the break.
We assume the next 4-months are compared with the same 4-month period in the previous year, taking annual logarithmic differences.
The sophists] said that 'the same Coriscus is sometimes in the market-place and sometimes in the Lyceum.
The current eligibility norm to qualify for group life is a minimum of 30 hours a week, though some employers negotiate that figure down to 20 hours, according to Sames.
Une methode elaboree initialement pour la langue same du Nord, encore prototypique de l'oralite pure--malgre son evolution typologique rapide depuis l'adoption d'sune orthographe unifiee en 1979--a permis de degager, sur la base d'une analyse de corpus large, une typologie [des Questions (Q) et] des Reponses (R) distinguant R simple (delimitee par une intonation terminative, ne contient qu'une predication principale) [pas egale a] R complexe (delimitee de meme, mais contient deux ou plus de deux predications coordonnees ou subordonnees) [pas egale a] R multiple (succession d'enonces lies par un tempo rapide).
Aggressive behavior has also been used as a taxonomic character to differentiate species of the same genus, as in Scolymia (Lang 1971), Acropora (Potts 1978) and Montastraea (Weil and Knowlton 1994).
HAT607) ARNOLD DRATT, CEO of SAMES CORPORATION (BIN), describes the company's business and its background; prospects for the industry, with positive and negative trends; competitive threats; strategic opportunities for the firm including its marketing plans and acquisition potential; management strength and organization; and the financial prospects of the firm looking forward.
There is no reason to suppose in advance that whenever sames represent sames, sameness must represent sameness.
Panda, which is the prototype phase of product development for Sames, a division of Binks, made the tools on its EDM machine using stainless steel and exotic plastics to increase product life.
The original margarita recipe is credited to American socialite Margarita Sames, who reportedly created the drink for her Acapulco guests 46 years ago.