saliva substitutes

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saliva substitutes

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Therapeutic: saliva substitutes
Pregnancy Category: UK


Management of dry mouth or throat, which may occur as a consequence of:
  • Medications (tricyclic antidepressants, antihistamines, anticholinergics),
  • Radiation therapy,
  • Chemotherapy,
  • Sjogren's syndrome,
  • Other illnesses,
  • Emotional factors.


Composition is similar to that of saliva.
Contains electrolytes in a thickening agent (carboxymethylcellulose).

Therapeutic effects

Relief of dry mouth.


Absorption: Minimal with local administration; electrolytes may be minimally absorbed through oral mucosa or with swallowing.
Distribution: Action is primarily local.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile (relief of dry mouth)



Contraindicated in: Hypersensitivity to carboxymethylcellulose, parabens, or other components.
Use Cautiously in: Situations in which absorption of electrolytes may compromise the patient’s condition, such as potassium and magnesium in patients with renal failure or sodium in patients with HF or hypertension.

Adverse Reactions/Side Effects

Fluid and Electrolyte

  • excessive absorption of electrolytes


Drug-Drug interaction

None significant.


Oral (Adults) Spray or apply to oral mucosa as needed.

Availability (generic available)

SolutionMoi-Stir—mint flavor; Mouthkote—citrus flavor: in squirt bottle, pump spray, spray canOTC
Swabs: Packets of 3OTC
Lozenges: Packages of 100OTC

Nursing implications

Nursing assessment

  • Assess patient for xerostomia (dry mouth) or dry throat before and periodically throughout therapy.
  • Assess gingiva and oral mucosa for stomatitis.

Potential Nursing Diagnoses

Impairedoral mucous membrane (Indications)


  • Administer as necessary for xerostomia or dry throat.

Patient/Family Teaching

  • Instruct patient to swish saliva substitute around in mouth after spray or application.
  • Advise patient of the importance of good oral hygiene in addition to the use of saliva substitutes.
  • Emphasize the importance of routine dental examinations throughout course of therapy.

Evaluation/Desired Outcomes

  • Decrease in dry mouth and throat.
References in periodicals archive ?
Sucking on sugar-free lozenges or chewing sugarless gum may help stimulate saliva production, and you also may want to try Salivart, an "artificial saliva" which is available over-the-counter.
Among these are Biotine, Salivart, Oralube, Xero-Lube, Orazyme, and Plax.
Salivart is sprayed directly into the mouth and throat and can be swallowed.
CLEVELAND -- Gebauer Company, a 107-year-old medical device manufacturer and marketer, today announced a nationwide, voluntary firm initiated recall of certain lots of its Salivart Oral Moisturizer, product number 0386-0009-75.
Use of the affected units of these lots of Salivart Oral Moisturizer may cause temporary and reversible health problems such as nausea, vomiting, and diarrhea.
Your doctor may recommend an over-the-counter artificial saliva product such as Salivart, Biotene, or Aquoral, which will help to keep your mouth moist; or may prescribe medications to help your salivary glands function more effectively.
Unlike some other synthetic saliva preparations, Salivart does not contain ingredients that aggravate the condition, cause allergic reactions, irritate the stomach, or have a drying effect.
Salivart lubricates and moistens oral tissue, thus facilitating speaking, chewing, and swallowing.
Salivart closely emulates human saliva, coating the oral mucosa to provide fast, temporary relief.
One half-second spray of Salivart Synthetic Saliva coats the oral cavity and works like natural saliva to immediately provide relief of dry mouth and dry throat.
Salivart [R] Synthetic Saliva provides immediate relief from xerostomia caused by ENT surgery and certain diseases, therapies, drugs or aging.
Pharmacy Times' annual survey has named Salivart the leading pharmacist-recommended OTC synthetic saliva for the last five years.