safrole

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Related to Safrol: sassafras oil

saf·role

(saf'rōl),
The methylene ether of allyl pyrocatechol; contained in oil of sassafras, oil of camphor, and various other volatile oils; it is obtained chiefly from oil of camphor by fractional distillation; formerly used as a tonic and carminative; prolonged administration causes fatty degeneration.

safrole

Toxicology
An oily phenylpropene extracted from the root-bark or the fruit of sassafras (Sassafras albidum), as well as camphor and other volatile oils. Once used as a carminative, intestinal tonic, topical antiseptic and pediculoside, it is hepatotoxic, causing fatty degeneration, and is carcinogenic; it is listed by the FDA as unsafe.
References in periodicals archive ?
Despues del correspondiente proceso de purificacion, se lograron aislar dos componentes de los frutos; el trans-Z-alfa-bisaboleno (A) y el Safrol (B) (Fig.
El Safrol fue aislado e identificado por la base de datos del equipo, este compuesto no presento actividad antiparasitaria contra Leishmania sp.
En estudios mas recientes se evaluo la actividad anti-Leishmania del aceite esencial del P.auritum, indicandose que dentro de los componentes mas abundantes esta el Safrol en un 86.91 %.
El efecto insecticida del dilapiol puede tambien estar relacionado a la accion de otros compuestos bioactivos minoritarios como el safrol (HUANG et al., 1999) y sarisan (BIZZO et al., 2001).
Posee como constituyentes anetol, phelandrene, safrol e hidroquinona-etil-eter (Fluckiger, 1879).
Se le reportan 40 componentes quimicos, los principales compuestos son, asarona, safrol, [beta]-ocimeno, [gamma]-terpineno y alcohol patchouli (Frischkorn et al.
fragrans Houtt has been reported to contain 25-30% fixed oils and 5-15% volatile oils such as camphene, elemicin, eugenol, isoelemicin, isoeugenol, methoxyeugenol, pinene, sabinene, safrol, etc., and also chemical substances such as dihydroguaiaretic acid, elimicin, myristic acid, myristicin and lignan compounds (Janssen et al., 1990; Kuo, 1989; Isogai et al., 1973; Forrest and Heacock, 1972).
They include organic acids (acetic, benzoic, cinnamic and phenylacetic); alcohols (benzyl alcohol, borneol, cinnamyl alcohol, citronellol, geraniol, linalool, menthol, phenylethyl alcohol and terpineol); aldehydes (anisic aldehyde, cinnamic aldehyde, benzaldehyde, citral, piperonal or heliotropin, salicylic aldehyde and vanillin); ketones (carvones, camphor, thujone, pulegone, etc; esters such as bornyl acetate, methyl salicylate, benzyl benzoate, geranyl acetate and linalyl acetate); phenols (thymol, carvacrol and chavicol); phenol ethers (anethol, eugenol and safrol) and many other more complex compounds such as coumarin and indol.