Sabin-Feldman dye test

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Sa·bin-Feld·man dye test

(sā'bĭn feld'măn),
a method for the detection of antitoxoplasma antibody in serum, based on the finding that Toxoplasma gondii cells (from peritoneal exudate in mice) are fairly well stained with alkaline methylene blue, whereas organisms in a serum that contains specific antibody have no affinity for the dye; furthermore, normal toxoplasma cells become rounded, and the nucleus and cytoplasm deeply stained, when treated with methylene blue; conversely, when dye is mixed with organisms and antibody, the cells retain their crescent shape and only the shrunken nuclear endosome is stained.

Sabin-Feldman dye test

[sā′bin feld′mən]
Etymology: Albert B. Sabin, American virologist, 1906-1993; H.A. Feldman, American epidemiologist, b. 1914; AS, deag + L, testum, crucible
a serological test for the diagnosis of toxoplasmosis that depends on the presence of specific antibodies that block the uptake of methylene blue dye by the cytoplasm of the Toxoplasma organisms.


Harry Alfred, U.S. epidemiologist, 1914–.
Sabin-Feldman dye test - see under Sabin
Sabin-Feldman syndrome - see under Sabin


Albert Bruce, U.S. epidemiologist, 1906-1993.
Sabin-Feldman dye test - a method for the detection of antitoxoplasma antibody in serum.
Sabin-Feldman syndrome - chorioretinitis and cerebral calcifications.
Sabin vaccine - an orally administered vaccine containing live, attenuated strains of poliovirus.
References in periodicals archive ?
Serumlarda seropozitiflik, Sabin-Feldman Dye Test (SFDT) ve Indirekt Hemaglutinasyon (IHA) testi ile saptanmistir.
5] takizoit inokulumu ile enfekte edilen parenteral gruplardan Sabin-Feldman Dye Test (SFDT) ve Indirekt Hemaglutinasyon (IHA) ile elde edilen pozitif serolojik test sonuclarinin oransal dagilimlari Parenteral Enfeksiyon Grubu ([10.
It is recommended that serological monitoring be performed consistently using the same manufacturer's test, and that confirmation of results from ECLIA should rely on methods such as Western blot or Sabin-Feldman dye test rather than on alternative automated assays.