ABCC8

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ABCC8

A gene on chromosome 11p15.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC8 modulates ATP-sensitive K+ channels and insulin release.

Molecular pathology
ABCC8 mutations are linked to hyperinsulinaemic hypoglycaemia of infancy and type-2 diabetes.
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Although SUR1 is not included in ToxCast[TM], tolazamide was ranked in the top 5-10% in the islet and [beta] cell function models, in the top 10% for insulin sensitivity, and in the top 15% for feeding behavior in rodents (Table 3).
Tolbutamide and gliclazide block channels containing SUR1 ([beta]-cell type) but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide block both types of the channels [104].
2 and SUR1 components of the sulfonylurea receptor affect sulfonylurea therapeutic efficacy and adverse effects.
ATP]) in the pancreatic islet [beta] cells by binding to the sulfonylurea SUR1 receptor, which causes depolarization of the [beta] cells followed by calcium influx and subsequent insulin secretion.
2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
2 and SUR1 subunits of the pancreatic ATP-sensitive potassium channel respectively have been implicated in the genesis of PNDM.
2 [encoded by potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) [4]] or SUR1 [encoded by ATP-binding cassette, sub-family C (cFTR/MRP), member 8 (ABCC8)] have been shown to cause neonatal diabetes (11).
And the common diabetes drug glyburide blocks the destructive SUR1 protein made by the gene.
The Skills Enhancement for Health Surveillance Program Online Modules EPI1 Basic Epidemiological Concepts EPI2 Measurement of Health Status EPI3 Epidemiological Methods APP1 Outbreak Investigation and Management APP2 Epidemiology of Chronic Diseases APP3 Applied Epidemiology: Injuries SUR1 Introduction to Surveillance SUR2 Communicating Data Effectively STA1 Basic Biostatistics Table 2.
481 TABLE 2 Seemingly Unrelated Regression (SUR) Results Panel A SUR1 School Interaction Term only Capital Stock Variables Growth TFP Growth FDI -0.
Mutations in the genes ABCC8 and KCNJ11 coding SUR1 and [K.