SUMO4

SUMO4

A gene on chromosome 6q25 that encodes a ubiquitin-like protein which can be covalently attached to target lysines. In response to oxidative stress, SUMO4 binds anti-oxidant enzymes, chaperones and stress-defence proteins (e.g., NFKBIA, TFAP2A and FOS), downregulating their transcription; it can also bind to others (e.g., NR3C1), upregulating them.
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References in periodicals archive ?
Shen et al., "Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris," Archives of Dermatological Research, vol.
Ornegin; HRM yontemiyle tip 2 diyabetli hastalarda SUMO4 gen polimorfizimleri analiz edilmis ve rs237025 polimorfizimin tip 2 diyabetle iliskili oldugu, fakat rs237024 ve rs600739 polimorfizimlerin iliskili olmadigi saptanmistir (45).
Association between SUMO4 polymorphisms and type 2 diabetes mellitus.
Overexpression of SUMO4 also contributes to enhancing the sumoylation of I[kappa]Ba and regulating NF-[kappa]B activation under external stimulus stimulation, which is considered to be strongly associated with type 1 diabetes [16].
Gong, "Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity," Biochemical and Biophysical Research Communications, vol.
Studying the association of 163A/G polymorphism of SUMO4 showed a positive significant association between AA carriers and diabetic nephropathy (P < 0.05) [93].
The following genes had significant association with diabetic nephropathy: eNOS, AT2R, SUMO4, IL-10, VEGF, MTHFR, ACE, and VDR.
Hedayati, "No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects," Diabetes Research and Clinical Practice, vol.
Besides these well-established non-HLA loci, a number of other associations with T1D have been reported for IL2RA/CD25 (52, 53), SUMO4 (small ubiquitinlike modifier 4) (54) and IFIH1 (55, 56).
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
An important role has been ascribed to a mutation identified in a gene-coding small ubiquitin-like modifier 4 (SUMO4) [11].
Lee, "Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: a meta-analysis," Human Immunology, vol.