SUMO3

SUMO3

A gene on chromosome 21q22.3 that encodes a broadly expressed ubiquitin-like protein, which can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of protein (sumolyation) plays a crucial role in a number of cellular processes, including nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO3 interacts with SAE2, UBE2I and USP25; it is activated when its precursor form is cleaved by SENP1, SENP2 or SENP5. It is also a less preferred gene symbol for what is now designated as SUMO2, see there.
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Our previous results from gene microarray analysis showed that SUMO3 gene might be associated with carcass and meat quality traits of cattle.
Primers and PCR amplification: Primers were designed according to the published sequence of the bovine SUMO3 gene (Gene Bank accession number: NM_001076449) with Primer Premier 5.
PCR-RFLP analysis: The PCR products of SUMO3 gene were subjected to PCR-RFLP analysis.
Associations of SUMO3 gene polymorphisms with the carcass traits were carried out using two-way ANOVA with SPSS 13.
SUMO3 PCR amplification: P1 (524 bp) and P2 (1158 bp) of SUMO3 gene were PCR amplified from the 375 Chinese Simmental cattle, as shown in figure.
As shown in figure 1-B, an A/G peak at I1-2653 appeared, which suggested a SNP site of an A/G substitution at position 2653 bp of SUMO3 gene intron1.
A C/T peak at 3'UTR-1120 of SUMO3 was found, which suggested a SNP site of a C/T substitution, as shown in figure.
Association analysis of SUMO3 SNPs with the carcass and meat quality traits: In this study, the associations of SUMO3 gene polymorphisms with the carcass and meat quality traits were analyzed by Two-Way ANOVA using SPSS 13.
And cattle with the AG heterozygotes of SUMO3 gene had higher score of fat coverage than those with the G allele homozygotes (p<0.
For 3'UTR SNPs of SUMO3 gene, individuals with the TT genotype was significantly associated with higher dressing percentage, hind leg circumference, eye muscle area (p<0.
Association analyses of SUMO3 gene polymorphisms with carcass and meat quality traits in Chinese Simmental cattle population.
In our study, two polymorphic loci, one in the first intron 27 and the other in the 3'UTR of the SUMO3 gene were found to be significantly or extremely significantly associated with the carcass weight, hind leg circumference, hind leg length, loin thickness, fat coverage of carcass, rib eye area, dressing percentage, hind hoof weight and back fat thickness.