SUMO3

SUMO3

A gene on chromosome 21q22.3 that encodes a broadly expressed ubiquitin-like protein, which can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of protein (sumolyation) plays a crucial role in a number of cellular processes, including nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO3 interacts with SAE2, UBE2I and USP25; it is activated when its precursor form is cleaved by SENP1, SENP2 or SENP5. It is also a less preferred gene symbol for what is now designated as SUMO2, see there.
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Small ubiquitin-related modifier 3(SUMO3) is a member of a growing family of ubiquitin-like proteins which is related to post-translational protein modification.
Primers and PCR amplification: Primers were designed according to the published sequence of the bovine SUMO3 gene (Gene Bank accession number: NM_001076449) with Primer Premier 5.
PCR-RFLP analysis: The PCR products of SUMO3 gene were subjected to PCR-RFLP analysis.
Associations of SUMO3 gene polymorphisms with the carcass traits were carried out using two-way ANOVA with SPSS 13.0.
SUMO3 PCR amplification: P1 (524 bp) and P2 (1158 bp) of SUMO3 gene were PCR amplified from the 375 Chinese Simmental cattle, as shown in figure.1-A and figure.2-A.
As shown in figure 1-B, an A/G peak at I1-2653 appeared, which suggested a SNP site of an A/G substitution at position 2653 bp of SUMO3 gene intron1.
A C/T peak at 3'UTR-1120 of SUMO3 was found, which suggested a SNP site of a C/T substitution, as shown in figure.2-B.
Association analysis of SUMO3 SNPs with the carcass and meat quality traits: In this study, the associations of SUMO3 gene polymorphisms with the carcass and meat quality traits were analyzed by Two-Way ANOVA using SPSS 13.0.
And cattle with the AG heterozygotes of SUMO3 gene had higher score of fat coverage than those with the G allele homozygotes (p<0.05).
For 3'UTR SNPs of SUMO3 gene, individuals with the TT genotype was significantly associated with higher dressing percentage, hind leg circumference, eye muscle area (p<0.05) than those with the C allele homozygotes.
Association analyses of SUMO3 gene polymorphisms with carcass and meat quality traits in Chinese Simmental cattle population.
Previous research revealed that PIASy preferentially stimulates site-selective modification of IKK[gamma] by SUMO1, but not SUMO2 and SUMO3, in vitro.