SUMO1

SUMO1

A gene on chromosome 2q33 that encodes a ubiquitin-like protein, which can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of protein (sumolyation) plays a crucial role in a number of cellular processes, including nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 may also regulate a network of genes involved in palate development. It interacts with CHD3, EXOSC9, HIF1A, HIPK2, HIPK3, PARK2, PIAS1, PIAS2,  RAD51, RAD52, RANBP2, SAE2, UBE2I and USP25.
 
Molecular pathology
Defects in SUMO1 cause non-syndromic orofacial cleft type 10.
References in periodicals archive ?
Sumocor is developing small molecule therapeutics that target SUMO1, a "chaperone" protein that regulates the activity of key transporter genes, which is deficient in the failing heart.
The team evaluated failing human and pig hearts and discovered that SUMO1, a so-called "chaperone" protein that regulates the activity of key transporter genes, was decreased in failing hearts.
When the researchers injected SUMO1 into these hearts via gene therapy, cardiac function was significantly improved.
This research indicates that SUMO1 may play a critical role in the pathogenesis of heart failure.
Our experiments over the last four years beginning with the discovery of SUMO1 as an interacting protein of SERCA2a have shown that it plays a critical role in the development of heart failure," said lead researcher Roger J.