SUMO1A gene on chromosome 2q33 that encodes a ubiquitin-like protein, which can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of protein (sumolyation) plays a crucial role in a number of cellular processes, including nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 may also regulate a network of genes involved in palate development. It interacts with CHD3, EXOSC9, HIF1A, HIPK2, HIPK3, PARK2, PIAS1, PIAS2, RAD51, RAD52, RANBP2, SAE2, UBE2I and USP25.
Defects in SUMO1 cause non-syndromic orofacial cleft type 10.