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The covalent attachment of a small ubiquitin-related modifier (SUMO) to substrate protein, a process that is biochemically analogous to, but functionally distinct from, ubiquitination; sumoylation is critical to many different biological processes—e.g., protein localisation and stability, transcriptional activities, nucleocytoplasmic signalling and transport, genome replication, and regulation of gene expression
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The researchers first used an automated process to examine whether the compounds prevented SENP2 from severing the connection between a tiny metal bead and an artificial SUMO protein created in the lab of Wei Yang, Ph.
We excluded the possibility of a reaction with SUMO protein by testing with the control protein.
SUMO protein production platforms have been used to manufacture industrial, research and therapeutic proteins.
SUMO proteins are important regulators of cell signalling, and are covalently linked to other proteins in order to alter structure, localization or function.
These key SUMO proteins produce subtle responses to the brain's activity levels to regulate the amount of information transmitted by kainate receptors - responsible for communication between nerve cells and whose activation can lead to epileptic seizures and nerve cell death.