Han et al., "Overexpression of STRA8
, BOULE, and DAZL genes promotes goat bone marrow-derived mesenchymal stem cells in vitro transdifferentiation toward putative male germ cells," Reproductive Sciences, vol.
Our result raised another direct regulator of Sohlh1, which may be the main regulator in differentiation of SSC.Recently,Ngn3 was reported function in promoting meiosis by up-regulating Stra8, an important gene in spermatogenesis(Tang et al., 2014).
Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8. Cell proliferation.
STRA8 is one of these proteins and is known to be imperative for the switch from mitosis to meiosis in both human male and female germ lines .
Roepers-Gajadien et al., "Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice," Proceedings of the National Academy of Sciences of the United States of America, vol.
The heterogenicity of the cells led us to sort them based on the expression of Stra8, which is regulated by RA.
Our cells exhibited 80% purity in the expression of Stra8 gene, which is activated by RA.
(1996) en ratas, haciendo posible la activacion del gen Stra8 para que pueda iniciarse la diferenciacion de las CMP (Oulad-Abdelghani et al.
Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene.
Chemically mediated alteration of expression of Stra8 (stimulated by retinoic acid gene 8) differentially affects the timing of meiosis in the ovary and testes and could influence sex.
The Stra8 has been shown to be required for both male and female germ cells to transition into meiosis.