STRA6


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STRA6

A gene on chromosome 15q24.1 that encodes a putative high-affinity cell surface receptor for the retinol-retinol-binding protein (RBP/RBP4) complex, which acts by removing retinol and transporting it across the plasma membrane where it is metabolised.

Molecular pathology
Defects in STRA6 cause microphthalmia syndromic type 9 and isolated colobomatous microphthalmia.
References in periodicals archive ?
El gen STRA6 codifica para una proteina de membrana involucrada en el metabolismo del retinol.
Al mismo tiempo, el gen ARD1 regula significativamente genes y sus vias descendentes, entre ellos el gen STRA6 cuya mutacion origina el Sindrome PDAC perteneciente a las microftalmias asociadas.
5 Estas dos vias metabolicas se conectan a traves del gen ARDI (N-a-acetiltransferasa 10), el cual estimula al gen HIF1 (Factor inducido por hipoxia) y este al gen VEGF (angiogenesis), y por otra parte, con al gen STRA6 causante del Sindrome PDAC.
Until the new study, the way STRA6 transports vitamin A into the cell had been a mystery.