Holo-retinol-binding protein and its receptor STRA6
drive oncogenic transformation.
These genes encoded proteins primarily involved in integrin signalling pathways (ACTA2, PIK3C2G, COL4A6, CAV1, LAMA1, FN1, and ITGA8), regulation of hormone levels (NR5A1, TIPARP, ACE, CRYM, CGA, ALDH1A1, TBX3, POMC, GHRH, and ALDH6), camera-type eye development (TGFBR2, BMP4, FABP7, STRA6
, SIX6, and WNT6), blood vessel development (Figure S1, goo.gl/tC9GTZ), and regulation of cellular response to growth factor stimulus (see Figure 2).
Alterations in dosage-sensitive transcription factor genes (such as SOX2 (OMIM 184429), OTX2 (OMIM 600037), and PAX6 (OMIM 607181)) and retinoic acid metabolism genes (such as STRA6
(OMIM 610745), ALDH1A3 (OMIM 600463), and RARB (OMIM 180220)) .
RBP's role in inducing inflammation through NADPH and NF-[kappa]B pathways occurs independently of STRA6
and retinol .
Thomas et al., "Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6
," American Journal of Human Genetics, vol.
Li, "Association of Polymorphisms in STRA6
and RARRES2 genes with type 2 diabetes in Southern Han Chinese," BioMed Research International, vol.
Este sindrome es causado por mutaciones en el gen "estimulado por el acido retinoico-6" (STRA6; locus 15q24).
Al mismo tiempo, el gen ARD1 regula significativamente genes y sus vias descendentes, entre ellos el gen STRA6 cuya mutacion origina el Sindrome PDAC perteneciente a las microftalmias asociadas.
http://bit.ly/MDT161007 Electron Microscopy Reveals How Vitamin A Enters the Cell Using a new, lightning-fast camera paired with an electron microscope, Columbia University Medical Center scientists have captured images of one of the smallest proteins in our cells, known as STRA6
, to be "seen" with a microscope.
This complex is recognized via the stimulated by retinoic acid 6 (STRA6
) receptor, which mediates the absorption of extracellular retinol to cytosol .
(stimulated by retinoic acid 6), a transmembrane protein, is the only characterized RBP4 receptor .