STK4

STK4

A gene on chromosome 20q11.2-q13.2 that encodes a ubiquitously expressed, stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK4 and STK3 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis.
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The data was confirmed by real time PCR for 10 miRNAs (let-7c, miR-10b, miR-26a, miR-26b, miR-29c, miR-30a, miR-29a, miR-29a, miR-30b, miR-30c, miR-148a, and miR-299), and the target genes were subsequently validated (CDC6, CCNE1, MYBL2, PDCD10, ERBB2IP, SON, STK4, CDC27, PRC1, CDC37, TTK, SKIL, BUB3, and SPIN1).
The MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, consists of five related proteins: STK3 (also known as MST2), STK4 (also known as MST1), STK24 (also known as MST3), STK25 (also known as YSK1), and STK26 (also known as MST4) [19].
In humans, studies have indicated that patients lacking STK4, which is a closely related paralog of STK3, showed T- and B-cell lymphopenia and recurrent bacterial and viral infections [29, 30].