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Variants of this human gene influence blood pressure by increasing STK39 expression and consequently altering renal sodium excretion by working at the distal nephron.
We collected the genotype data by using the tetra primer ARMS-PCR technique to detect the STK39 Single Nucleotide Polymorphism rs35929607 as this method is quite rapid, simple, cost effective and accurate.
20] FASTA sequence showing point mutation in STK39 gene at SNP rs35929607 was obtained from the NCBI website.
Keywords: Serine-threonine kinase-39 (STK39) gene, Single nucleotide polymorphism (SNP) STK39 rs35929607, Essential hypertension, Cardiovascular diseases, STK39 Genotypes, Effect size of Risk Factors, Pakistani population.
The odds ratio of STK39 rs35929607 with essential hypertension was 3.
In a European study carried out in 2009, the STK39 gene SNP rs35929607 were coincidently associated significantly with systolic and diastolic blood pressure, (p less than0.
According to the results of a study being published online in the Proceedings of the National Academy of Sciences (PNAS), the STK39 gene is the first hypertension susceptibility gene to be uncovered through a new technique called a genome-wide association study and confirmed by data from several independent studies.
The STK39 gene is only one important piece of the puzzle," she says.
The University of Maryland researchers identified the link between the STK39 gene and blood pressure by analyzing the DNA of 542 members of the Old Order Amish community in Lancaster County, Pennsylvania, scanning approximately 100,000 genetic markers across the entire genome for variants known as single nucleotide polymorphisms, or SNPs, associated with systolic and diastolic blood pressure.
20,21] The STK39 is expressed in the distal nephron and influence the blood pressure by altering renal Na+ excretion  It was found that rs35929607 is a conserved nucleotide within a highly conserved sequence element.
2 with positive history of consanguinity and the 2 from purely non-consanguineous families for comparative assessment of mode of transmission of EHTN by carrying out genotyping for the STK39 single nucleotide polymorphism at rs35929607.
24] FASTA sequence showing point mutation in STK39 gene at SNP rs35929607 was obtained from the National Center for Biotechnology Information (NCBI) website.
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