STK12 | definition of STK12 by Medical dictionary
AURKB (redirected from STK12)
AURKB A gene on chromosome 17p13.1 that encodes Aurora kinase B, which is involved in regulating many mitotic events. Aurora B is the catalytic component of the chromosomal passenger complex (CPC), which is critical for the correct progression through and completion of mitosis. It phosphorylates the CPC subunits BIRC5/survivin, CDCA8/borealin and INCENP, the last of which increases AURKB activity.
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References in periodicals archive
For example, the let-7 family has been shown to repress multiple genes involved in cell cycle, cell apoptosis, and cell proliferation, including CCNA2, CDC34, AURA/STK6, AURKB/ STK12
, E2F5, and CDK8 .
The Aurora-B is encoded by the AURKB gene (also known as AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM1; STK12
), mapped to chromosome 17p13.1, and consisting of 9 exons (Gene ID: 9212).