STAT6


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STAT6

A gene on chromosome 12q13 that encodes a protein of the signal transducer and activator of transcription (STAT) family of transcription factors, which are involved in IL-4 signalling.
References in periodicals archive ?
5, synaptophysin, chromogranin, neuro N, neurofilaments;melanocytic cells: S100, HMB-45, MITF, Melan-A) and 18 fusion gene product markers or surrogates detected by IHC (FLI1, ERG, AP1 [beta], TLE1, ALK, ROS1, NR4A3, BCL2, WT1, MYC, NUT, BCL6, TFE3, ZAP70, MUC4 Lin and Doyle,(83) 2015 Thirteen new markers (ERG, MYC, MDM2/CDK4, STAT6, MUC4, DOG1, SDHB/A, INI1, TLE1, TFE3, SOX10, NY-ES0-1) Source, y Reference Hornick, (26) 2014 Mod Pathol.
Nuclear expression of STAT6 distinguishes solitary fibrous tumour from histologic mimics.
We designed Custom PrimeTime[R] Mini LNA probes and ZEN double-quenched hydrolysis probes (Integrated DNA Technologies) for EZH2 (Y641), STAT6 (D419), MYD88 (L265), and CCND3 (I290) hotspots, as described in the online Supplemental Methods file.
Deactivation of STAT6 through serine 707 phosphorylation by JNK.
Por el contrario, la diferenciacion de las celulas Th2 depende de estimulos que lleven a la produccion de IL-4 como los parasitos y los alergenos, que activan los factores de transcripcion STAT6, GATA-3 y c-Maf, llevan a la produccion del patron de citoquinas caracterizado por IL-4, IL-5 e IL-13 e inhiben el desarrollo de las celulas de tipo Th1.
5,591,825 covering STAT6 (Signal Transducer and Activator of Transcription 6), a protein which plays a key role in activating the immune response, and related drug discovery screening methodology.
Special immunohistochemical study for STAT6 may be helpful, which is shown to be a sensitive and specific marker of SFT.
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production.
More recently, nuclear staining for STAT6 has been shown to be a very sensitive and specific marker for solitary fibrous tumors.
STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics.