STAT6


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STAT6

A gene on chromosome 12q13 that encodes a protein of the signal transducer and activator of transcription (STAT) family of transcription factors, which are involved in IL-4 signalling.
References in periodicals archive ?
Transcription factors involved in the regulation of Th1/Th2 responses (a) Effects on Th2 Th1 Transcription factors phenotype phenotype STAT4 + STAT6 + BCL-6 - T-bet - + GATA-3 + - C-maf + NF-Atc + NF-ATp/NF-AT4 - (a) Th, T-helper; STAT, signal transducer and activator of transcription.
Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4/TNFalpha stimulated human epithelial cells.
29) Using immunohistochemistry, they could show that the antiinflammatory STAT6 signalling pathway is expressed mainly by oligodendrocytes, whereas the pro-inflammatory transcription factor STAT4 is expressed by microglia.